Successful Pregnancy in a Patient with Chronic Myeloid Leukemia under Treatment with Imatinib
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概要
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Contraception is recommended during imatinib therapy based on the teratogenicity data in rats. However, patients may become pregnant and here we describe a successful pregnancy and labor without any congenital anomaly in a patient with chronic myeloid leukemia (CML) under treatment with imatinib. The patient had received imatinib for 53 months before she became pregnant, with a complete cytogenetic response achieved after 6 months of therapy and a major molecular response (MMR) after 28 months. CML was in MMR at discovery of pregnancy and the fetus had been exposed to imatinib for 5 weeks. Treatment was discontinued, but MMR persisted during gestation.
著者
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Watanabe Masato
Department Of Energy Sciences Tokyo Institute Of Technology
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Hasegawa Akio
Department Of Applied Physics National Defense Academy
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MARUYAMA Fumio
Department of Phsics, Faculty of Science, Shinshu University
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Emi Nobuhiko
Department Of Hematology And Clinical Oncology Fujita Health University School Of Medicine
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YAMAMOTO Yukiya
Department of Breast & Endocrine Surgery, Kumamoto University
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TSUZUKI Motohiro
Department of Hematology and Medical Oncology, Fujita Health University School of Medicine
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OKAMOTO Masataka
Department of Hematology and Medical Oncology, Fujita Health University School of Medicine
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Okamoto Masataka
Department of Internal Medicine, Fujita Health University, School of Medicine
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Yamamoto Yukiya
Department of Internal Medicine, Fujita Health University, School of Medicine
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Tsuzuki Motohiro
Department of Internal Medicine, Fujita Health University, School of Medicine
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Inaguma Youko
Department of Internal Medicine, Fujita Health University, School of Medicine
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Handa Kousuke
Department of Internal Medicine, Fujita Health University, School of Medicine
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Mizuta Syuichi
Department of Internal Medicine, Fujita Health University, School of Medicine
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Watanabe Masato
Department of Internal Medicine, Fujita Health University, School of Medicine
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