Usefulness of Plasma BNP Levels as a Marker of Left Ventricular Wall Stress in Obese Individuals
スポンサーリンク
概要
- 論文の詳細を見る
Plasma brain natriuretic peptide (BNP) level is known to reflect left ventricular wall stress (LVWS). Recent studies have shown that obese individuals have lower BNP levels. However, the usefulness of BNP level as a marker of LVWS in obese individuals remains unclear. This study examined whether BNP reflects LVWS even in obese individuals.This study enrolled 136 hospital inpatients who had suffered chronic heart failure (NYHA class I or II), or who had undergone a thorough examination for angina pectoris. On the basis of body mass index (BMI), we divided the inpatients into nonobese (< 25) and obese (≥ 25) groups. All BNP measurements, cardiac catheterizations, and echocardiographic examinations were carried out within 24 hours. Although no significant differences were found between the two groups in the hemodynamic parameters examined, including end-diastolic LVWS (LV-EDWS) and end-systolic LVWS (LV-ESWS), BNP levels were significantly lower in the obese group compared to the nonobese group. In the nonobese group, a definite correlation between LV-EDWS or LV-ESWS and BNP (r = 0.43, r = 0.46, respectively) was observed, whereas no correlation was found between LV-EDWS or LV-ESWS and BNP in the obese group (r = -0.09, r = 0.06, respectively). To explore the mechanism for suppressed BNP levels in obese individuals, the correlation of BNP with biochemical markers was analyzed. Statistical significance was found only between adiponectin and BNP (r = 0.44), implying that BNP or adiponectin might influence the plasma levels of the other.In conclusion, BNP levels cannot be used as a marker of LVWS in obese individuals.
- インターナショナル・ハート・ジャーナル刊行会の論文
著者
-
Watanabe Hiroyuki
秋田大学 医学部内科学講座第二内科
-
Tosa Shinya
Second Department of Internal Medicine, Akita University School of Medicine
-
Watanabe Hiroyuki
Second Department of Internal Medicine, Akita University School of Medicine
-
Iino Kenji
Second Department of Internal Medicine, Akita University School of Medicine
-
Terui Gen
Akita Red Cross Hospital
-
Kosaka Toshimitsu
Second Department of Internal Medicine, Akita University School of Medicine
-
Hasegawa Hitoshi
Second Department of Internal Medicine, Akita University School of Medicine
-
Ito Hiroshi
Second Department of Internal Medicine, Akita University School of Medicine
-
Ito Hiroshi
Second Department Of Internal Medicine Tokyo Medical And Dental University
-
Hasegawa Hitoshi
Second Department Of Internal Medicine Akita University School Of Medicine
-
Watanabe Hiroyuki
Second Department Of Internal Medicine Akita University School Of Medicine
関連論文
- Fluvastatin Attenuates Diabetes-Induced Cardiac Sympathetic Neuropathy in Association With a Decrease in Oxidative Stress
- Oxygen Uptake Kinetics During and After Exercise are Useful Markers of Coronary Artery Disease in Patients With Exercise Electrocardiography Suggesting Myocardial Ischemia
- PJ-647 Short Term Effect of Adaptive Servo Ventilation on Muscle Sympathetic Nerve Activity in Patients with Chronic Heart Failure(PJ109,Heart Failure (Treatment) 3 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulati
- EXPERIMENTAL STUDY ON CORONARY STEAL PHENOMENON : Coronary Circulation IV : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- STUDIES ON THE MECHANISM OF ST DEPRESSIONS FOLLOWING SYMPATHETIC NERVE STIMULATION WITH SPECIAL RESPECTS TO THE ROLE OF MYOCARDIAL ISCHEMIA : Electrocardiography・Vectircarduigraphy I : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRC
- Usefulness of Plasma BNP Levels as a Marker of Left Ventricular Wall Stress in Obese Individuals
- CLINICAL OUTCOME OF AMIODARONE THERAPY IN PATIENTS WITH LIFETHREATENING RECURRENT REFRACTORY VENTRICULAR TACHYCARDIA : Arrhythmias (IV) : FREE COMMUNICATIONS (VI) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- 1010 EFFECTS OF TRAINING ON AUTONOMIC NERVE ACTIVITY AFTER CORONARY ARTERY BYPASS SURGERY
- 0997 CHANGES IN HEART RATE RESPONSE TO EXERCISE AND THE COEFFICIENT IN : KARVONEN'S FORMULA FOR AEROBIC EXERCISE TRAINING AFTER CORONARY BYPASS SURGERY
- Preload-Adjusted 2 Wave-Intensity Peaks Reflect Simultaneous Assessment of Left Ventricular Contractility and Relaxation
- PE-465 The 1st Peak of Wave-Intensity Analysis : This New Approach to LV Contractile Dynamics Index Varies With Cardiac Chamber Size(Cardiac Function, Basic/Clinical 3 (M) : PE79)(Poster Session (English))
- OE-246 The 2nd Peak of Wave-Intensity Analysis : This New Approach to LV Diastolic Filling Dynamics Index Varies with Cardiac Chamber Size(Heart Failure, Clinical 9 (M) : OE30)(Oral Presentation (English))
- Role of Low Sodium Hemodyalysis on Chronic Hemodyalysis Patients with Hypertension
- Cytokine abnormalities were related to thigh muscle volume and exercise impairment in heart failure patients
- The Effects of Posture on the Ventilatory Responses During Exercise
- Sex-Related Differences in the Risk Factor Profile and Medications of Patients With Atrial Fibrillation Recruited in J-TRACE
- Dose-Response Effects of Bepridil in Patients With Persistent Atrial Fibrillation Monitored With Transtelephonic Electrocardiograms : A Multicenter, Randomized, Placebo-Controlled, Double-Blind Study (J-BAF Study)
- Peak V^^・O_2 is More Potent Than B-Type Natriuretic Peptide as a Prognostic Parameter in Cardiac Patients
- Effects of Supplemental O_2 Inhalation on Cerebral Oxygenation During Exercise in Patients With Left Ventricular Dysfunction
- Influence of Cerebrovascular Arteriosclerosis on Cerebral Oxygenation During Exercise
- Differences of Soluble Tumor Necrosis Factor Receptor between Patients with Myocardial Infarction and after Coronary Artery Bypass Surgery Participating in a Cardiac Rehabilitation Program
- IS042 G1 Cyclin-Dependent Kinase Activity is Required for the Development of Cardiomyocyte Hypertrophy
- Pilsicainide-Induced Coronary Vasospasm in a Patient With Brugada-Type Electrocardiogram : A Case Report
- The Pathological Role of Transient Receptor Potential Channels in Heart Disease
- PJ-321 Neuron-Restrictive Silencing Factor (NRSF) is Responsible for Cardiac Hypertrophy by Regulating Expression of Transient Receptor Potential Channel 1 (TRPC1)(Cardiac hypertrophy, basic/clinical-4, The 71st Annual Scientific Meeting of the Japanese C
- Critical Level of Cerebral Oxygenation During Exercise in Patients With Left Ventricular Dysfunction
- PJ-655 Correlation of the Severity of Sleep Apnea to Cerebral Hypoxemia and Cardiac Sympathetic Stimulation in Obstructive Sleep Apnea (OSA) Patients(Cerebrovascular circulation/Stroke-3 (H) PJ110,Poster Session (Japanese),The 70th Anniversary Annual Scie
- PJ-390 Cerebral Oxygenation is Impaired during Exercise in Patients with Left Ventricular Dysfunction(Exercise test/Cardiac rehabilitation-3 (IHD) PJ66,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation So
- PJ-040 Does the Severity of Central Sleep Apnea Correlate with the Respiratory Gas Indexes during Cardiopulmonary Exercise Testing?(Exercise test/Cardiac rehabilitation-5 (IHD) PJ7,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting o
- Critical Level of Cerebral Oxygenation during Exercise in Patients with Dilated Cardiomyopathy(Cerebrovascular Circulation/Stroke 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Effects of a Calcium Channel Blocker on Cerebral Oxygenation during Exercise in Patients with High Blood Pressure(Hypertension, Clinical 1 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Early Aerobic Training Increases End-Tidal CO_2 Pressure During Exercise in Patients After Acute Myocardial Infarction
- PJ-481 Cerebral oxygenation during sleep in cardiac patients with sleep apnea syndrome(Cerebrovascular Circulation/Stroke 1 (H) : PJ80)(Poster Session (Japanese))
- PE-378 Anemia Mediated by Increased Proinflammatory Cytokines is Associated with Reduced Exercise Capacity in Patients with Cardiac Disease(Exercise Test/Cardiac Rehabilitation 7 (IHD) : PE65)(Poster Session (English))
- OJ-534 Prognostic Value of Heart Rate Variability for All Cause and Sudden Death in Patients with Renal Failure on Hemodialysis(Kidney/Renal Circulation 3 (H) : OJ65)(Oral Presentation (Japanese))
- 1007 EFFECTS OF AEROBIC TRAINING ON CARDIAC AND VENTILATORY RESPONSE DURING EXERCISE IN ACUTE MYOCARDIAL INFARCTION
- Ca^ Overload Evokes a Transient Outward Current in Guinea-Pig Ventricular Myocytes
- P465 CHANGES IN HEART RATE RESPONSE TO EXERCISE AFTER ACUTE MYOCARDIAL INFARCTION
- Cardiopulmonary Responses at Various Angles of Cycle Backrest Inclination
- Disparate Effects of Exercise Training on Exercise Tolerance in Myocardial Infarction Patients with and without Insulin Resistance
- The effect of cardiac rehabilitation and its relevancy to tumor necrosis factor-alpha in acute myocardial infarction
- Physical training improves not only exercise capacity but also cytokine and neurohormonal abnormalities in chronic heart failure patients
- Effects of exercise training on health related quality of life in patients with congestive heart failure
- The relationship between functional capacity and muscle strength in patients with heart failure
- Prognostic Significance of Cardiopulmonary Exercise Testing for 10-Year Survival in Patients With Mild to Moderate Heart Failure
- Role and Relation of p70 S6 and Extracellular Signal-Regulated Kinases in the Phenotypic Changes of Hypertrophy of Cardiac Myocytes
- G_1 Cyclins are Involved in the Mechanism of Cardiac Myocyte Hypertrophy Induced by Angiotensin II
- -P469- Role of Endogenous Endothelin-1 in Stretch-Induced Cardiomyocyte Hypertrophy in Vitro(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Long-Term Prognosis in Patients with Silent Myocardial Ischemia (SMI)
- -276-PROGNOSIS OF VENTRICULAR TACHYCARDIA
- VENTRICULAR PREMATURE BEATS IN CHRONIC HEMODIALYSIS PATIENTS : FREQUENCY MECHAMISM AND PREVENTION : Arrhythmia : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- THE INFLUENCE OF MgSO_4 ON TRIGGERED ACTIVITY ARRHYTHMIAS IN THE INTACT CANINE HEART : Arrhythmias : 53 Annual Scientific Meeting, Japanese Circulation Society
- Mechanism of the Reduced Ventilatory Efficiency in Healthy Older Men
- Acute Effect of Pimobendan on Ventilatory Efficacy during Exercise in Patients with Heart Failure : Results of Placebo Controlled Double-Blind Trial
- THE EFFECT OF AEROBIC EXERCISE TRAINING ON VO_2 KINETICS AND METOBOLIC RESPONSE TO EXERCISE IN ESSENTIAL HYPERTENSIVES
- PJ-683 Left Atrial Strain Rate Imaging can be Useful for the Evaluation of Thromboembolic Risk in Patients with Paroxysmal Atrial Fibrillation(PJ115,Thromboembolism/Antithrombotic Therapy/Thrombolysis (IHD),Poster Session (Japanese),The 73rd Annual Scient
- -0939-DOXORUBICIN SELECTIVELY INHIBITS MUSCLE SPECIFIC GENE EXPRESSION IN CARDIOCYTES IN VITRO AND IN VIVO : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- OJ-495 Effects of cerebrovascular arteriosclerosis on cerebral oxygenation during exercise(Exercise Test/Cardiac Rehabilitation 8 (IHD) : OJ60)(Oral Presentation (Japanese))
- OJ-349 The level of serum hemoglobin (Hb) is an additional useful parameter for evaluating prognosis in cardiac patients.(Exercise Test/Cardiac Rehabilitation 4 (IHD) : OJ42)(Oral Presentation (Japanese))
- OJ-313 Cerebral oxygenation during exercise and exercise recovery in patients with dilated cardiomyopathy(Heart Failure, Clinical 9 (M) : OJ37)(Oral Presentation (Japanese))
- High Diastolic Blood Pressure during Exercise Is Associated with the Level of Serum Cholesterol
- Factors Determining Cerebral Oxygenation during Exercise in Cardiac Patients
- Relationship between Baroreflex Sensitivity and Exercise Capacity in Patients with Chronic Heart Failure
- Peak VO_2 Is more Potent Than Brain Natriuretic Peptide (BMP) as a Prognostic Parameter in Cardiac Patients
- Relation between Cerebral Oxygenation during Exercise and Cerebrovascular Arteriosclerosis
- Effects of Nitric Oxide inhalation on Periodic Breathing in Awake Patients with Chronic Heart Disease
- Cerebral oxygen saturation during maximal exercise in patients with valvular disease
- Four resections for hepatic metastasis from gastric cancer: histochemical analysis of cell proliferation, apoptosis, and angiogenesis
- Reresection for Local Recurrence of Rectal Cancer
- PJ-794 Waon Therapy Improves Exercise Tolerance Primarily through Improvement of Endothelial Function in Patients with Heart Failure(PJ133,Heart Failure (Treatment) 4 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circula
- PJ-110 The Effect of Combined Use of Angiotensin Receptor Blocker with Statin on Coronary Plaque Composition(PJ019,Atherosclerosis (Clinical/Treatment) 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ
- -1015-TRANSESOPHAGEAL ECHOCARDIOGRPHY MONITORING DURING ABDOMINAL ANEURYSMAL SURGERY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0219-POSTPRANDIAL HEMODYNAMIC CHANGES EVALUATED BY A DOPPLER ECHOCARDIOGRAPHIC METHOD
- PJ-450 Impaired Renal Function is Associated with Blunted Heart Rate Recovery Immediately after Exercise(PJ076,Exercise Test/Cardiac Rehabilitation 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-301 Amiodarone Improves the Abnormality of Circadian Variation of Autonomic Function in Rats with Chronic Heart Failure(PJ051,Autonomic Nervous System (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-428 Evaluation of Atrial versus Ventricular Effects of Bepridil in Patients with Persistent Atrial Fibrillation Using Frequency Analysis of Fibrillation Waves(PJ072,Atrial/Supraventricular Arrhythmia (Clinical/Treatment) 2 (A),Poster Session (Japanese)
- PJ-426 D,I-Sotalol Reverses Atrial Electrical Remodeling and Prevents Atrial Fibrillation Promotion without Affecting Down-regulated L-type Ca2+ Channel mRNA Expression(PJ072,Atrial/Supraventricular Arrhythmia (Clinical/Treatment) 2 (A),Poster Session (Ja
- Impairment of Coronary Microcirculation in Patients with Diabetes Mellitus without Overt Coronary Artery Lesions : A Myocardial Contrast Echocardiographic Study
- CARDIAC AUTONOMIC NERVOUS ACTIVITY DURING EXERCISE-INDUCED MYOCARDIAL ISCHEMIA:THE DIFFERENCE BETWEEN SYMPTOMATIC AND ASYMPTOMATIC MYOCARDIAL ISCHEMIA
- 0429 Effects of Calcium Antagonism and Beta-Blockade on the Heart Under Chronic Nitric Oxide Synthase Inhibition in Rat
- -P096- Effects of Diltiazem on the Myocardial Structure and Coronary Vasculature Under Chronic Nitric Oxide Synthase Inhibition in in vivo Rat Model(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -0807- The Efficacy of Three Years Aerobic Exercise Training (ET) on Hypertensive Patients(HT)(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- Improved Oxygen Utilization During Mild Exercise in Heart Failure
- PE-139 Detection of Endocardia! Ischemia by Myocardial Contrast Echocardiography : Comparison of Perfusion between Endocardium and Epicardium(Coronary Circulation, Basic/Clinical 1 (IHD) : PE24)(Poster Session (English))
- PE-044 IKca as a New Therapeutic Target for Vascular Remodeling(Endothelium/NO 1 (H) : PE8)(Poster Session (English))
- Down-regulation of Large Conductance Calcium-activated Potassium Channel Expression in Atherosclerotic Arteries
- Altered Expression of Intermediate Conductance Calcium-Activated Potassium Channels Induced by Long-Term Blockade of Nitric Oxide Synthesis
- Guidelines for Pharmacotherapy of Atrial Fibrillation (JCS 2008) : Digest Version
- FRS-071 Premature Senescence can be Induced by Oxidative Stress via PML-p53 Acetylation Pathway in Cardiomyocytes(Heart Failure Research (M) FRS15,Featured Research Session,The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society
- The Subcellular Localization of Cyclin A Regulates Apoptosis of Cardiomyocytes Induced by Doxorubicin(Heart Failure, Basic 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Senescence-like Alterations by Oxidative Stress is Novel Mechanism of Cardiomyocyte Dysfunction(Heart Failure, Basic 4 (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-277 HMG-CoA Reductase Inhibitor Pevents Agiotensinll-Induced Cardiac Hypertrophy through Inhibition of CyclinD1 Expression via Rho kinase.(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (English))
- -0979-TWO-DIMENSIONAL ECHOCARDIOGRAPHY GUIDED PERCUTANEOUS ENDOMYOCARDIAL BIOPSY : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- MYOPOTENTIAL INHIBITION OF VVI PACEMAKER: CLINICAL EVALUATION BY 24-HOUR HOLTER ECG AND PECTORAL MUSCLE EXERCISES : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Arrhythmia
- Lack of a relation between oscillatory ventilation during wakefulness and prognosis in patients with left ventricular dysfunction
- Significance of plasma brain natriuretic peptide concentration during exercise testing in cardiac patients
- Investigation of optimal anticoagulation strategy for stroke prevention in Japanese patients with atrial fibrillation : The J-RHYTHM Registry study design
- Present Status of Anticoagulation Treatment in Japanese Patients With Atrial Fibrillation : A Report From the J-RHYTHM Registry
- Primary sarcoma of the right ventricle : surgical and adjuvant therapy
- OJ-067 Up-regulation of TRPC1 in the Development of Cardiac Hypertrophy(Cardiac hypertrophy, basic/clinical-2 (M) OJ12,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)