Clinical Features of Japanese Elderly Patients with Type 1 Autoimmune Hepatitis
スポンサーリンク
概要
- 論文の詳細を見る
Objective In Caucasian type 1 autoimmune hepatitis patients with a main susceptibility of human leukocyte antigen DR3 and DR4, elderly patients have a higher frequency of concurrent autoimmune disease and cirrhosis at presentation. However, in Japanese patients, the disease is dominantly associated with DR4, and their clinical features may be different from those of previous reports. In this study, we assessed the clinical features of Japanese elderly patients with type 1 autoimmune hepatitis. Methods We investigated 160 consecutive patients with type 1 autoimmune hepatitis, consisting of 34 elderly patients (≥65 years) and 126 younger patients (<65 years). Results There were no differences in form of clinical onset, frequencies of concurrent autoimmune disease, positive proportions of anti-nuclear antibody and/or anti-smooth muscle antibody, and human leukocyte antigen DR status between the two groups. However, the elderly patients had lower serum levels of albumin (p=0.0049), and higher frequencies of cirrhosis (F4) and pre-cirrhosis (F3) (p=0.014) compared with the younger patients. In contrast, in elderly patients, the cumulative incidental rate of the normalization of serum alanine aminotransferase levels within 6 months after the introduction of initial treatment was higher in those treated with prednisolone ≥20 mg/day than those treated only with ursodeoxycholic acid (p=0.001). Conclusion We speculate that more years may pass between the occurrence of the disease and the presentation in Japanese elderly patients than in younger patients, and we considered that, even in elderly patients, those with advanced fibrosis should be treated with prednisolone in order to prevent progress of the disease into liver failure.
- 社団法人 日本内科学会の論文
著者
-
Takaki Akinobu
Department Of Gastroenterology & Hepatology Okayama University Graduate School Of Medicine Denti
-
Kobashi Haruhiko
Department Of Gastroenterology & Hepatology Okayama University Graduate School Of Medicine Denti
-
Sakaguchi Kohsaku
Department Of Gastroenterology & Hepatology Okayama University Graduate School Of Medicine Denti
-
Miyake Yasuhiro
Department Of Gastroenterology & Hepatology Okayama University Graduate School Of Medicine Denti
-
Iwasaki Yoshiaki
Department Of Diagnostic Pathology Graduate School Of Medicine The University Of Tokyo
-
SHIRATORI Yasushi
Department of Gastroenterology & Hepatology, Okayama University Graduate School of Medicine and Dentistry, Okayama
-
Shiratori Yasushi
Department of Gastroenterology & Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
-
Kobashi Haruhiko
Department of Gastroenterology & Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
-
Miyake Yasuhiro
Department of Gastroenterology & Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
関連論文
- Totally Laparoscopic Distal Gastrectomy Using the Hand-Sewn Billroth-I Anastomotic Technique : Report of a Case
- Analysis of factors influencing hepatocellular carcinoma detection : efficient use of computed tomography during arterial portography and during hepatic arteriography
- Congenital absence of portal vein with multiple hyperplastic nodular lesions in the liver
- Hepatocellular carcinoma depicted as hypoattenuation on CT hepatic arteriography (CTA) and hyperattenuation on CT during arterial portography (CTAP)
- Platelet conut reflects stage of chronic hepatitis C
- Enhancement of Endothelial Nitric Oxide Production by Chenodeoxycholic Acids in Patients with Hepatobiliary Diseases
- Mortality rate of patients with asymptomatic primary biliary cirrhosis diagnosed at age 55 years or older is similar to that of the general population
- Clinical features of type 1 autoimmune hepatitis in adolescence and early adulthood
- Clinical features of antinuclear antibodies-negative type 1 autoimmune hepatitis
- Pachydermoperiostosis associated with juvenile polyps of the stomach and gastric adenocarcinoma
- Analysis of the β-Catenin/T Cell Factor Signaling Pathway in 36 Gastrointestinal and Liver Cancer Cells
- Frameshift Mutations at Mononucleotide Repeats in RAD50 Recombinational DNA Repair Gene in Colorectal Cancers with Microsatellite Instability
- PE-227 Alterations of Heart Rate and Heart Rate Variability after Slowpathway Radiofrequency Catheter Ablation. : Comparison during daytime with nighttime(ECG/Body Surface Potential Mapping/Holter 4 (A) : PE39)(Poster Session (English))
- Exponential-Exponential Cosine Fitting of Blood Pressure Decay by a Long-Acting Calcium Channel Blocker, Amlodipine, Using Home-Blood Pressure Measurement
- Relationship between R-R Interval (RR-l) and Maximal-Flow-Velocity of Aorta as a Marker of Cardiac Performance in Patients with Chronic Non-Valvular Atrial Fibrillation (NVAF)
- PJ-568 Fractional Flow Reserve (FFR) by Fullback (PB) Method to Predict Restenosis and Target Lesion Revascularization : Comparison with Conventional (C) Method(Restenosis after Angioplasty, Basic/Clinical 7 (IHD) : PJ95)(Poster Session (Japanese))
- PJ-167 Increase of Escape Rhythms with Years after Radiofrequency Ablation of Atrioventricular-junction Combined with Pacemaker (Ablate and Pace) in Atrial Fibrillation(Arrhythmia, Non-Pharmacological Therapy 6 (A) : PJ28)(Poster Session (Japanese))
- PJ-297 Changes in Serum Interferon-gamma Inducible Protein 10 (IP-10) Levels Correlated with Ventricular Function and Infarct Size in Myocardial Infarction Patients(Acute myocardial infarction, clinical (diagnosis/treatment)-8 (IHD) PJ50,Poster Session (J
- Lp3/Hapln3 Expression is Coordinately Upregulated with Versican in Balloon-injured Artery and is Enhanced by PDGF in Arterial Smooth Muscle Cell (Restenosis after Angioplasty, Basic/Clinical 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circ
- Evidence for the Proteolytic Cleavage of Versican in Infarct Heart (Old Myocardial Infarction/Remodeling 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-065 Increments of serum chemokine interferon-gamma inducible protein 10 (IP-10) levels correlated with left ventricular function in acute myocardial infarction patients(Acute Myocardial Infarction, Clinical (Pathophysiology) 3 (IHD) : PJ11)(Poster Sess
- OE-312 Vasl1 (Vascular Link Protein-1) Is a Novel Extracellular Matrix Protein Limited To Vessels and Is Upregulated in Pressure Overload Heart(Hypertension, Basic 3 (H) : OE39)(Oral Presentation (English))
- OE-278 Low dose of Cerivastatin increased microvessel formation and induced angiogenesis in conjunction with attenuating antiangiogenic protein in rat myocardial infarction(Cardiovascular Pharmacology, Basic/Clinical 1 (H) : OE34)(Oral Presentation (Engli
- OE-072 Serum Antibodies to Human Heat Shock Protein 60 Is Elevated in Subjects With Unstable Angina Pectoris(Acute Coronary Syndrome, Basic/Clinical 3 (IHD) : OE9)(Oral Presentation (English))
- FRS-078 ADAMTS-1, A Disintegrin And Metalloprotease with ThromboSpondin motifs-1, Is a Novel Hypoxic Immediate Gene Expressed by Endothelial Cells(NO and Cardiovascular System (H) : FRS10)(Featured Research Session (English))
- Endothelial Cells of Newly Formed Vessels in the Border Zone of Myocardial Infarction Express Proteoglycan Decorin and Biglycan
- Metalloprotease ADAMTS-1 Was Rapidly Expressed by Endothalial Cells in Acute Myocardial Infarction and Its Quantitative Analysis by Real-Time PCR
- Dynamic Induction of ADAMTS1 Gene in the Early Phase of Acute Myocardial Infarction
- Efficacy of Clinical Pathway for the Management of Mucosal Gastric Carcinoma Treated with Endoscopic Submucosal Dissection Using an Insulated-tip Diathermic Knife
- Pneumocystis carinii pneumonia in patients with ulcerative colitis
- A monoclonal antibody to rat asialoglycoprotein receptor that recognizes an epitope specific to its major subunit
- CONCURRENT GASTRIC AND COLONIC LOW-GRADE MUCOSA-ASSOCIATED LYMPHOID TISSUE LYMPHOMATA IN A PATIENT WITHOUT HELICOBACTER PYLORI INFECTION
- Acute Hepatitis due to Hepatitis E Virus Genotype 1 As an Imported Infectious Disease in Japan
- Human leukocyte antigen DR status and clinical features in Japanese patients with type 1 autoimmune hepatitis
- Increase in Connective Tissue Growth Factor (CTGF) Expression Precedes Extrracellular Matrix (ECM) Gene Expressions in Pressure-overload Heart in Rats (Hypertension, Basic 5 (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Dietary Intake, Neutrophil Fatty Acid Profile, Serum Antioxidant Vitamins and Oxygen Radical Absorbance Capacity in Patients with Ulcerative Colitis
- Meta-analysis : the effect of interferon on development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
- A 27-year-old man who died of acute liver failure probably due to trichloroethylene abuse
- Mutational Inactivation of Mitotic Checkpoint Genes, hsMAD2 and hBUB1, Is Rare in Sporadic Digestive Tract Cancers
- A model for estimating cirrhosis in patients with type 1 autoimmune hepatitis
- Fibrosis progression rates between chronic hepatitis B and C patients with elevated alanine aminotransferase levels
- Clinical features of Japanese type 1 autoimmune hepatitis patients with zone III necrosis
- Early detection and quantification of lamivudine-resistant hepatitis B virus mutants by fluorescent biprobe hybridization assay in lamivudine-treated patients
- Development of an automatic Doppler flow signal detection system : variability of pulmonary and aortic peak flow velocity
- Clinicopathological features of acute-onset autoimmune hepatitis
- Identification of genes associated with sensitivity to 5-fluorouracil and cisplatin in hepatoma cells
- The Second Virial Coefficients of Polymer Solutions
- On the Internal Rotation in Polymer Chains
- Laparoscopic findings of reddish markings predict hepatocellular carcinoma in patients with hepatitis B virus-related liver disease
- Development of Hepatocellular Carcinoma in a Woman with HBV- and HCV-negative Autoimmune Hepatitis with Unsatisfactory Response to Corticosteroid
- Different clinicopathological features of hepatocellular carcinoma in relation to causative agents
- Partial splenic embolization prior to combination therapy of interferon and ribavirin in chronic hepatitis C patients with thrombocytopenia
- Scattering Function of Self-Avoiding Chain (n=0 Vector Model); Calculation and Experiments
- Refractive Index Difference of Dilute Aqueous Solution of Polyvinylpyrolidon
- Partial Splenic Embolization Facilitates the Adherence to Peginterferon in Chronic Hepatitis C with Thrombocytopenia
- Effect of pegylated interferon therapy on intrahepatic recurrence after curative treatment of hepatitis C virus-related hepatocellular carcinoma
- Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma
- SIRS Score Reflects Clinical Features of Non-Acetaminophen-Related Acute Liver Failure with Hepatic Coma
- Gastric carcinoma with osteoclast-like giant cells : Lymphoepithelioma-like carcinoma with Epstein-Barr virus infection is the predominant type
- Long-term Combined Therapy with Very-low-dose Peginterferon and Ursodeoxycholic Acid Decreased the Spleen Size in a Patient with Hepatitis C Virus-related Cirrhosis
- Clinical Features of Japanese Elderly Patients with Type 1 Autoimmune Hepatitis
- Lamivudine Treatment Improves the Prognosis of Fulminant Hepatitis B
- Usefulness of Early-phase Peritoneal Lavage for Treating Severe Acute Pancreatitis
- Peritoneal Dissemination of Hepatocellular Carcinoma Treated with a Combination Therapy of Interferon-alpha-2b and Oral Tegafur/Uracil
- Santorinicele in a Patient with Unresectable Pancreatic Cancer
- Recommendation of lamivudine-to-entecavir switching treatment in chronic hepatitis B responders : Randomized controlled trial
- Primary biliary cirrhosis-Autoimmune hepatitis overlap syndrome : A rationale for corticosteroids use based on a nation-wide retrospective study in Japan
- Long-term outcome and hepatocellular carcinoma development in chronic hepatitis B or cirrhosis patients after nucleoside analog treatment with entecavir or lamivudine
- Fulminant henatitis : Who survives without liver transplantation?
- Dynamic Induction of ADAMTS1 Gene in the Early Phase of Acute Myocardial Infarction
- Sepsis-associated liver injury : Incidence, classification and the clinical significance
- The impact of patatin-like phospholipase domain-containing protein 3 polymorphism on hepatocellular carcinoma prognosis