Association between Uric Acid and Carotid Atherosclerosis in Elderly Persons
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概要
- 論文の詳細を見る
Objective Several cohort studies have shown a link between serum uric acid (SUA) and subsequent cardiovascular disease. However, such an association did not remain significant after adjusting for concomitant risk factors for atherosclerosis in some studies. Thus, the role of SUA as an independent risk factor remains controversial. We therefore investigated the association between SUA and sclerotic lesions of common carotid atherosclerosis.Patients and Methods We evaluated sclerotic lesions of the common carotid arterial intima-media thickness (IMT) by ultrasonography in 398 men aged 74±8 (range, 60-97) years and 521 women aged 75±8 (range, 60-104) years. To investigate the relation between SUA and various factors, all subjects were divided into three groups based on the tertile of SUA.Results Stepwise multiple linear regression analysis using IMT as an objective variable, adjusted by various risk factors as explanatory variables showed that SUA [B, 0.0099; 95% confidence interval (CI), 0.0022-0.0175] was a significant independent contributing factor along with known risk factors such as age, sex, smoking status, systolic blood pressure, diastolic blood pressure, antihypertensive drug use, HDL-cholesterol, and LDL-cholesterol. Multiple logistic regression analysis for carotid IMT as a tertile of SUA and dependent variables showed that the adjusted odds ratio was 1.25 (95% CI, 0.87-1.78) for those in the middle tertile (4.2-5.5 mg/dl), and 1.66 (95% CI, 1.16-2.39) for those in the highest tertile (5.6-14.1 mg/dl) compared to that for subjects in the lowest tertile of SUA levels (0.51-4.1 mg/dl).Conclusion We suggest that SUA is a risk factor or marker for ultrasonographically determined IMT.
著者
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Kawamoto Ryuichi
Department of Internal Medicine, Nomura Municipal Hospital
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KAMITANI Atsushi
Department of Electrical and Information Engineering,Faculty of Engineering,Yamagata University
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Kawamoto Ryuichi
Department Of Community Medicine Ehime University Graduate School Of Medicine
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Kawamura Ryoichi
Department Of Molecular And Genetic Medicine Ehime University Graduate School Of Medicine
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Kodama Akihiro
Department Of Internal Medicine Seiyo Municipal Nomura Hospital
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Kawamoto Ryuichi
Department Of Internal Medicine Nomura Municipal Hospital
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Kawamoto Ryuichi
Department Of Internal Medicine Seiyo Municipal Nomura Hospital
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OKA Yuichiro
Department of Internal Medicine, Nomura Municipal Hospital
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Oka Yuichiro
Department Of Internal Medicine Seiyo Municipal Nomura Hospital
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TOMITA Hitomi
Department of Internal Medicine, Seiyo Municipal Nomura Hospital
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Oka Yuichiro
Department Of Internal Medicine Nomura Municipal Hospital
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Tomita Hitomi
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
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OHTSUKA Naoko
Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Ehime
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Kamitani Atsushi
Department Of Applied Physics Faculty Of Engineering The University Of Tokyo
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KAMITANI Atsushi
Department of Internal Medicine, Kamitani Clinic, Osaka
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Kodama Akihiro
Department of Gastroenterology, Ehime Prefectural Central Hospital
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