Carotid Atherosclerosis in Normal-Weight Metabolic Syndrome
スポンサーリンク
概要
- 論文の詳細を見る
Objective To examine whether or not individuals with a normal body mass index (BMI) (18.5 kg/m2-24.9 kg/m2), but who also fulfill the criteria for the metabolic syndrome (MetS) class, can be associated with carotid atherosclerosis. Methods The subjects were consecutive in-patients with a normal BMI (18.5 kg/m2-24.9 kg/m2) in the Medical Department of Seiyo Municipal Nomura Hospital enrolled between September 1996 and February 2006. The subjects were 452 men aged 69±15 (mean±standard deviation) years and 542 women aged 74±13 years. Carotid atherosclerosis was assessed by carotid intima-media thickness (IMT) on B-mode ultrasonography. Results Compared with men with BMI 18.5 kg/m2 to 20.9 kg/m2, the odds ratios of the MetS were 2.83 (95% confidence interval [CI], 1.69-4.76) for men with BMI 21 kg/m2 to 22.9 kg/m2 and 6.13 (95% CI, 3.57-10.5) for men with BMI 23.0 kg/m2 to 24.9 kg/m2 after controlling for age, smoking status, high low-density lipoprotein cholesterol, and uric acid. Using the same regression model and BMI categories in women, the odds ratios were 2.52 (95% CI, 1.42-2.83) and 4.38 (95% CI, 2.42-7.92), respectively. Multivariate-adjusted carotid IMT was significantly greater in men with than without MetS, especially in patients with BMI 23.0 kg/m2 to 24.9 kg/m2. Although in women, there were no inter-group differences in categories of normal BMI and MetS. Conclusion Individuals in the upper normal BMI range have a relatively high prevalence and are at increased risk of having metabolic syndrome. Therefore, screening of individuals with normal or slightly elevated BMI is important in preventing atherosclerosis.
- 社団法人 日本内科学会の論文
著者
-
Ninomiya Daisuke
Department Of Chemistry Faculty Of Science And Engineering Konan University
-
Kawamoto Ryuichi
Department Of Community Medicine Ehime University Graduate School Of Medicine
-
Ohtsuka Nobuyuki
Department Of Internal Medicine Nomura Municipal Hospital
-
OHTSUKA Nobuyuki
Department of Internal Medicine, Seiyo Municipal Nomura Hospital
-
Nakamura Syunpei
Department of Internal Medicine, Seiyo Municipal Nomura Hospital
関連論文
- An Association between Decreased Estimated Glomerular Filtration Rate and Arterial Stiffness
- Serum Gamma-Glutamyl Transferase Levels are Associated with Metabolic Syndrome in Community-Dwelling Individuals
- Alcohol Consumption Is Associated with Decreased Insulin Resistance Independent of Body Mass Index in Japanese Community-Dwelling Men
- High Prevalence of Prehypertension Is Associated with the Increased Body Mass Index in Community-Dwelling Japanese
- Association between Serum Gamma-Glutamyl Transferase Level and Prehypertension among Community-Dwelling Men
- An Association between Body Mass Index and Estimated Glomerular Filtration Rate
- Synthesis and Conformational Study of Tripeptides Containing the Amino Acid with a Pyridine Ring
- A Pilot Study Suggests that the G/G Genotype of Resistin Single Nucleotide Polymorphism at -420 May Be an Independent Predictor of a Reduction in Fasting Plasma Glucose and Insulin Resistance by Pioglitazone in Type 2 Diabetes
- Synthesis and Conformational Study of Tripeptides Containing the Amino Acid with a Pyridine Ring (2)
- Effect of Genetic Polymorphism of OATP-C (SLCO1B1) on Lipid-Lowering Response to HMG-CoA Reductase Inhibitors
- An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis
- Influence of living alone on emotional well-being in community-dwelling elderly persons
- Risk factors for insomnia in community-dwelling older persons
- Factors related to functional capacity in community-dwelling elderly
- An Association between an Antibody against Chlamydia pneumoniae and Ischemic Stroke in Elderly Japanese
- Significance of Serum Circulating Hepatocyte Growth Factor in the Development of Carotid Atherosclerosis
- An Association between Plasma Homocysteine Concentrations and Ischemic Stroke in Elderly Japanese
- Angiotensin-Converting Enzyme Gene Deletion Allele Disappear Brachial-Carotid Pulse Pressure Amplification
- Aging and metabolic syndrome effect on carotid atherosclerosis assessed by ultrasonography
- Relationship between Serum Uric Acid Concentration, Metabolic Syndrome and Carotid Atherosclerosis
- Metabolic Syndrome Amplifies the LDL-Cholesterol Associated Increases in Carotid Atherosclerosis
- Association between Uric Acid and Carotid Atherosclerosis in Elderly Persons
- Metabolic Syndrome as a Predictor of Ischemic Stroke in Elderly Persons
- Association of Plasma Homocysteine Concentrations with Carotid Atherosclerosis in Elderly Japanese
- Non-HDL Cholesterol as a Predictor of Carotid Atherosclerosis in the Elderly
- Association between Abdominal Wall Fat Index on Ultrasonography and Carotid Atherosclerosis in Non-obese Men
- Metabolic Syndrome, Diabetes and Subclinical Atherosclerosis as Assessed by Carotid Intima-Media Thickness
- Metabolic Syndrome may be a Risk Factor for Early Carotid Atherosclerosis in Women but not in Men
- Impact of C-reactive Protein on the Likelihood of Carotid Atherosclerosis in Japanese Adults
- Blood Pressure Is the Main Determinant of the Reflection Wave in Patients with Type 2 Diabetes
- Predictors of functional status in Japanese community-dwelling older persons during a 2-year follow up
- Metabolic Syndrome and Carotid Atherosclerosis : Role of Elevated Blood Pressure
- An Association of 5, 10-Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism and Ischemic Stroke
- Double cancer of the stomach, one AFP-producing tumor
- Self-reported functional ability predicts three-year mobility and mortality in community-dwelling older persons
- Sleep problems as a risk factor for fall in community-dwelling older persons
- An Interaction between Systolic Blood Pressure and Angiotensin-Converting Enzyme Gene Polymorphism on Carotid Atherosclerosis
- An Association between the Estimated Glomerular Filtration Rate and Carotid Atherosclerosis
- Association between Risk Factors and Carotid Enlargement
- A single-nucleotide polymorphism in the human THADA gene is associated with circulating resistin in the general Japanese population
- The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population
- Hunting for genes for hypertension : the Millennium Genome Project for Hypertension
- Carotid Atherosclerosis in Normal-Weight Metabolic Syndrome