Association between Risk Factors and Carotid Enlargement
スポンサーリンク
概要
- 論文の詳細を見る
Objective: The aim of this study was to evaluate the influence of conventional cardiovascular risk factors on the degree of adaptive response of the carotid arterial wall to atherosclerotic disease. Patients and Methods: We evaluated the diameter and intima-media thickness (IMT) of common carotid artery (CCA) by ultrasonography in 351 men aged 70.3 (range, 14-97) years and 474 women aged 75.6 (range, 19-103) years in the medical department of Seiyo Municipal Nomura Hospital. We assessed cross-sectionally the relationships between CCA diameter and IMT and cardiovascular risk factors by gender. Results: In multiple linear regression analyses, after controlling for traditional cardiovascular risk factors, a significant correlation was found between CCA diameters and age (p=0.034), body mass index (BMI) (p<0.001), smoking status (p=0.039), alcohol consumption (<0.001) and uric acid (UA) (p=0.021) in men, and between CCA diameters and age (<0.001), BMI (p<0.001), systolic blood pressure (SBP) (p=0.013) and antihypertensive drug use (p=0.005) in women. Analysis of covariance showed that the two regression lines between carotid IMT and diameter in those with or without plaque were significantly different in both men (F=16.4; p<0.001) and women (F=15.0; p<0.001). After adjustment for carotid IMT and plaque, associations with carotid diameters still persisted for age (p<0.001), BMI (p<0.001), smoking status (p=0.006), alcohol consumption (p<0.001) and SBP (p=0.001) in men, and age (p=0.005), BMI (p<0.001), SBP (p=0.047) and UA (p=0.001) in women. Conclusion: This study shows that the CCA diameters correlated with conventional cardiovascular risk factors including alcohol consumption. These findings suggest that the CCA diameters may reflect the ability of adaptive remodeling to the atherosclerosis before plaque formation and can be an important factor during the development of atherosclerosis.
著者
-
Ohtsuka Nobuyuki
Department of Internal Medicine, Nomura Municipal Hospital
-
Kawamoto Ryuichi
Department Of Community Medicine Ehime University Graduate School Of Medicine
-
OKA Yuichiro
Department of Internal Medicine, Nomura Municipal Hospital
-
Ohtsuka Nobuyuki
Department Of Internal Medicine Nomura Municipal Hospital
-
Oka Yuichiro
Department Of Internal Medicine Nomura Municipal Hospital
-
Tomita Hitomi
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
関連論文
- An Association between Decreased Estimated Glomerular Filtration Rate and Arterial Stiffness
- Serum Gamma-Glutamyl Transferase Levels are Associated with Metabolic Syndrome in Community-Dwelling Individuals
- Alcohol Consumption Is Associated with Decreased Insulin Resistance Independent of Body Mass Index in Japanese Community-Dwelling Men
- High Prevalence of Prehypertension Is Associated with the Increased Body Mass Index in Community-Dwelling Japanese
- Association between Serum Gamma-Glutamyl Transferase Level and Prehypertension among Community-Dwelling Men
- An Association between Body Mass Index and Estimated Glomerular Filtration Rate
- A Pilot Study Suggests that the G/G Genotype of Resistin Single Nucleotide Polymorphism at -420 May Be an Independent Predictor of a Reduction in Fasting Plasma Glucose and Insulin Resistance by Pioglitazone in Type 2 Diabetes
- Effect of Genetic Polymorphism of OATP-C (SLCO1B1) on Lipid-Lowering Response to HMG-CoA Reductase Inhibitors
- An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis
- Influence of living alone on emotional well-being in community-dwelling elderly persons
- Risk factors for insomnia in community-dwelling older persons
- Factors related to functional capacity in community-dwelling elderly
- An Association between an Antibody against Chlamydia pneumoniae and Ischemic Stroke in Elderly Japanese
- Significance of Serum Circulating Hepatocyte Growth Factor in the Development of Carotid Atherosclerosis
- Association between Abdominal Wall Fat Index and Carotid Atherosclerosis in Women
- An Association between Plasma Homocysteine Concentrations and Ischemic Stroke in Elderly Japanese
- Angiotensin-Converting Enzyme Gene Deletion Allele Disappear Brachial-Carotid Pulse Pressure Amplification
- Aging and metabolic syndrome effect on carotid atherosclerosis assessed by ultrasonography
- Relationship between Serum Uric Acid Concentration, Metabolic Syndrome and Carotid Atherosclerosis
- Metabolic Syndrome Amplifies the LDL-Cholesterol Associated Increases in Carotid Atherosclerosis
- Association between Uric Acid and Carotid Atherosclerosis in Elderly Persons
- Metabolic Syndrome as a Predictor of Ischemic Stroke in Elderly Persons
- Association of Plasma Homocysteine Concentrations with Carotid Atherosclerosis in Elderly Japanese
- Non-HDL Cholesterol as a Predictor of Carotid Atherosclerosis in the Elderly
- Association between Abdominal Wall Fat Index on Ultrasonography and Carotid Atherosclerosis in Non-obese Men
- Metabolic Syndrome, Diabetes and Subclinical Atherosclerosis as Assessed by Carotid Intima-Media Thickness
- Metabolic Syndrome may be a Risk Factor for Early Carotid Atherosclerosis in Women but not in Men
- Impact of C-reactive Protein on the Likelihood of Carotid Atherosclerosis in Japanese Adults
- Blood Pressure Is the Main Determinant of the Reflection Wave in Patients with Type 2 Diabetes
- Predictors of functional status in Japanese community-dwelling older persons during a 2-year follow up
- Metabolic Syndrome and Carotid Atherosclerosis : Role of Elevated Blood Pressure
- An Association of 5, 10-Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism and Ischemic Stroke
- Double cancer of the stomach, one AFP-producing tumor
- Self-reported functional ability predicts three-year mobility and mortality in community-dwelling older persons
- Sleep problems as a risk factor for fall in community-dwelling older persons
- An Interaction between Systolic Blood Pressure and Angiotensin-Converting Enzyme Gene Polymorphism on Carotid Atherosclerosis
- An Association between the Estimated Glomerular Filtration Rate and Carotid Atherosclerosis
- Association between Risk Factors and Carotid Enlargement
- A single-nucleotide polymorphism in the human THADA gene is associated with circulating resistin in the general Japanese population
- The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population
- Hunting for genes for hypertension : the Millennium Genome Project for Hypertension
- Carotid Atherosclerosis in Normal-Weight Metabolic Syndrome