Usefulness of Carperitide for the Treatment of Refractory Heart Failure due to Severe Acute Myocardial Infarction

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概要

• 論文の詳細を見る

• Carperitide (synthetic atrial natriuretic peptide) is a newly developed drug for the treatment of heart failure. Although this drug has been used for various types of heart failure, it remains unknown whether it has additive effects on hemodynamic parameters or renal excretory function during intensive treatment for acute refractory heart failure. We have examined the cardiorenal and hormonal effects of carperitide (0.05-0.10 μg / min / kg) in 9 patients (mean age: 67±8 years) with severe heart failure complicated with acute myocardial infarction, in which a range of intensive treatments have already been started. Hemodynamic parameters were determined before and 4, 24 and 48 hours after initiation of carperitide. Pulmonary capillary wedge pressure (mean±SD) had decreased dramatically from 21±6 to 11±5 mmHg (p<0.01) 4 hours after the treatment without significant renal effects. Heart rate and systemic blood pressure were not significantly changed. These beneficial effects were maintained for at least 24 hours. Plasma aldosterone levels fell significantly in response to the drug (from 148±68 to 56±29 pg / ml; p<0.05). However, mean hourly urine output remained unchanged after carperitide. In conclusion, intravenous infusion of carperitide promptly and persistently reduces left ventricular filling pressure without diuresis, hypotension, reflex tachycardia, or neurohormonal activation in patients with refractory heart failure due to severe acute myocardial infarction.

• Japanese Heart Journal Associationの論文

著者

• NAKAMURA Motoyuki

  Second Department of Internal Medicine, School of Medicine, Iwate Medical University

• Hiramori Katsuhiko

  岩手医科大学医学部附属循環器医療センター

• Hiramori Katsuhiko

  Second Department Of Internal Medicine Iwate Medical University

• Sato Madoka

  Second Department of Internal Medicine, Iwate Medical University

• Kikuchi Migaku

  Second Department of Internal Medicine, School of Medicine, Iwate Medical University

• Suzuki Tomomi

  Second Department of Internal Medicine, School of Medicine, Iwate Medical University

• Takino Toshitake

  Second Department of Internal Medicine, School of Medicine, Iwate Medical University

• Nakamura Motoyuki

  Secon Department Of Internal Medicine Memorial Heart Center

• Hiramori Katsuhiko

  Second Department of Internal Medicine, School of Medicine, Iwate Medical University

• Hiramori Katsuhiko

  Second Department of Internal Medicine and Department of Hygiene, School of Medicine, Iwate Medical University

• Sato Madoka

  Second Department of Internal Medicine, School of Medicine, Iwate Medical University

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