Association between Serum C-reactive Protein Levels and Microalbuminuria : A Population-Based Cross-Sectional Study in Northern Iwate, Japan

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•   Objective  The presence of microalbuminuria is a renal marker of vascular endothelial damage, and is an independent and strong predictor of increased risk for cardiovascular mortality and morbidity. Elevated circulating C-reactive protein (CRP) levels have recently been reported to be a novel cardiovascular risk factor, and it has been suggested that this acute-phase protein impairs vascular endothelial function. The aim of the present study was to determine whether serum CRP level is a dependent or an independent risk factor of microalbuminuria in the general population.  Methods  Subjects of this cross-sectional study were apparently healthy individuals drawn from the general Japanese population (mean age, 62; men, 2, 236; women, 4, 217). Serum CRP levels were determined using a highly sensitive kit and urine albumin-creatinine ratio (UACR) was calculated using a single urine sample. Multivariate logistic regression analysis was used to determine which risk factors (ie, age, hypertension, diabetes, obesity, hypercholesterolemia, smoking, and CRP) might predict the presence of microalbuminuria.  Results  In addition to classical cardiovascular risk factors such as age, hypertension, diabetes and obesity, serum CRP levels are also significantly correlated with microalbuminuria in men (odds ratio=1.42, 95% CI=1.13-1.79; p<0.01) and women (odds ratio=1.25, 95% CI=1.05-1.49; p<0.01). When subjects with diabetes were excluded from the analysis, serum CRP levels continued to be a significant predictor for microalbuminuria (odds ratio=1.35, 95% CI=1.06-1.73; p<0.05 for men: odds ratio=1.23, 95% CI=1.03-1.47; p<0.05 for women).  Conclusions  The present study has shown that low-grade inflammation as represented by high sensitivity CRP levels may be significantly related to the presence of microalbuminuria. This suggests that microalbuminuria may be a useful marker representing systemic low-grade inflammation as well as being an established cardiovascular risk factor in apparently healthy individuals.

• 社団法人　日本内科学会の論文
• 2004-10-01

著者

• OHSAWA Masaki

  Department of Hygiene and Preventive Medicine, Iwate Medical University

• NAKAMURA Motoyuki

  Second Department of Internal Medicine, School of Medicine, Iwate Medical University

• Haze Kazuo

  国立循環器病センター

• Sasaki Junko

  Iwate Health Service Association

• Hiramori K

  Memorial Heart Center The Second Division Of Internal Medicine Iwate Medical University

• Hiramori Katsuhiko

  岩手医科大学医学部附属循環器医療センター

• Hiramori Katsuhiko

  Second Department Of Internal Medicine Iwate Medical University

• Sakai Toshiaki

  Second Department of Internal Medicine, Iwate Medical University School of Medicine

• Ohsawa Masaki

  Department Of Hygiene And Preventive Medicine Iwate Medical University

• Segawa Toshie

  Divison Of Cardiology Department Of Medicine Iwate Medical Universiy

• Hotta Kazuhiko

  岩手医科大学 内科学第2

• Hosokawa Kazuya

  国立循環器病センター

• Segawa Toshie

  Second Department of Internal Medicine, Iwate Medical University

• Hiramori Katsuhiko

  Second Department Of Internal Medicine Iwate Medical University School Of Medicine

• Okayama Akira

  Department Of Orthopedic Surgery Hyogo College Of Medicine

• Itai Kazuyoshi

  Department Of Hygiene And Preventive Medicine Iwate Medical University

• Hiramori Katsuhiko

  Memorial Heart Center, The Second Division of Internal Medicine, Iwate Medical University

• Hiramori Katsuhiko

  2nd Department Of Internalmedicine And Critical Care And Emergency Center

• Ojima Toshiyuki

  Department Of Hygiene And Preventive Medicine Iwate Medical University

• Onoda Toshiyuki

  Hygiene and Preventive Medicine, Iwate Medical University

• Ohsawa Masaki

  Hygiene and Preventive Medicine, Iwate Medical University

• Itai Kazuyoshi

  Hygiene and Preventive Medicine, Iwate Medical University

• Tonari Yoko

  Iwate Health Service Association

• SATOU Kenyu

  Second Department of Internal Medicine, Iwate Medical University School of Medicine

• OKAYAMA Akira

  Hygiene and the Preventive Medicine, Iwate Medical University School of Medicine

• Nakamura Motoyuki

  Secon Department Of Internal Medicine Memorial Heart Center

• Segawa Toshie

  Department Of Internal Medchine Ii Iwate Medical University And Memorial Heart Center

• Segawa Toshie

  Second Department of Internal Medicine and Department of Hygiene, School of Medicine, Iwate Medical University

• Sakai Toshiaki

  Second Department of Internal Medicine, Iwate Medical University

• Hiramori Katsuhiko

  Second Department of Internal Medicine and Department of Hygiene, School of Medicine, Iwate Medical University

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