Creatine Kinase-MB Protein Mass Is a Better Indicator for the Assessment of Acute Myocardial Infarction in the Lower Range of Creatine Kinase Level.
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概要
- 論文の詳細を見る
The theoretical and clinical validity of immunochemiluminometric assay of creatine kinase (CK)-MB protein mass was assessed in patients with acute myocardial infarction and the results were compared with those of immunoinhibition assay of CK activity. Serial changes of both CK-MB protein mass and CK-MB activity were analyzed in 20 consecutive patients. In all 312 samples from 20 patients, protein mass and activity of CK-MB showed good correlation. The exponential fitting of the time-value curve of CK-MB protein mass showed a better correlation coefficient than that of CK-MB activity (0.97±0.02 vs 0.93±0.07, p<0.05), indicating that the CK-MB level measured by the immunochemiluminometric assay was less scattered than that measured by the immunoinhibition method. This finding was most evident at lower CK-MB values (<500IU/l). The rate of disappearance from serum of CK-MB protein mass was faster than that of CK-MB activity (0.54±0.23hr-1 vs 0.28±0.13hr-1, p<0.001). This may indicate that some amount of the CK-MB activity may be inactivated in the early phase of the release into the serum from the necrotic myocardium.Thus, the immunochemiluminometric assay of CK-MB protein mass has superiority in the diagnosis of acute myocardial infarction compared with the immunoinhibition method, especially when the measured CK-MB level is low. This feature may be useful to distinguish a small myocardial infarction from severe ischemia without myocardial necrosis.
- International Heart Journal刊行会の論文
著者
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NONOGI Hiroshi
Division of Cardiology, National Cardiovascular Center
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Haze Kazuo
Division Of Cardiology Department Of Medicine National Cardiovascular Center
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Hiramori Katsuhiko
Second Department Of Internal Medicine Iwate Medical University
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Furuno Takashi
Kochi Medical School, Department of Medicine and Geriatrics
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Miyazaki Shunichi
Division Of Cardiology Department Of Internal Kinki University School Of Medicine
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Seo Hiromi
Kochi AMI study group
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Nonogi Hiroshi
Division Of Cardiac Care Unit Department Of Cardiovascular Medicine National Cerebral And Cardiovasc
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MIYAZAKI Shunichi
Division of Cardiology, National Cardiovascular Center
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HIRAMORI Katsuhiko
Second Department of Medicine, Iwate Medical University, School of Medicine
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HAZE Kazuo
Division of Cardiology, National Cardiovascular Center
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FURUNO Takashi
Kochi Medical School
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Hiramori Katsuhiko
Second Department of Internal Medicine and Department of Hygiene, School of Medicine, Iwate Medical University
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