Association of Angiotensin I Converting Enzyme Gene Insertion/Deletion Polymorphism with the Renin-angiotensin System and Blood Pressure Response during a Single Bout of Exercise
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概要
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We investigated the association between Angiotensin I converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism and responses of hormonal factors related to vasoconstriction and volume loading of heart, enzyme activities of Renin-Angiotensin system, blood pressure and heart rate during a single bout of exercise. Six insertion homozygous (I/I) and 6 deletion homozygous (D/D) young men participated in this study. Subjects performed a multi-load exercise test at 1/2 lactate threshold (LT), LT, onset blood lactate accumulation (OBLA), and middle point of OBLA to maximum exercise load (OBLA-Peak) intensities. The duration of intensities was 10 minutes. Blood samples, blood pressure and heart rate were obtained at rest, in the last 2 minutes of every intensity, and 3 minutes after finishing exercise (recovery). However the plasma ACE activity in I/I was lower than that in D/D at rest, during exercise and recovery, and Angiotensin II was no different in I/I and D/D. Furthermore, there were no differences in plasma Renin activity, Angiotensin I, plasma aldosterone concentration, atrial natriuretic peptide, brain natriuretic peptide, adrenaline, noradrenalin, dopamine, systolic blood pressure, diastolic blood pressure, mean blood pressure, heart rate and double product at rest, during exercise and recovery. No relationship between plasma ACE activity and Angiotensin II existed, but plasma Angiotensin I and Angiotensin II had a positive correlation in I/I and D/D. This data suggests that the ACE gene I/D polymorphism is not associated with plasma Angiotensin II concentration during a single session of exercise.
著者
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Michishita Ryoma
Clinic of Tsuruta Orthopaedic Surgery
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Kiyonaga Akira
Faculty Of Sports And Health Fukuoka University
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Saku Keijiro
Department Of Cardiology Faculty Of Medicine Fukuoka University
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Tanaka Hiroaki
Faculty Of Engineering Kyoto University
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Bo Zhang
Department Of Biochemistry Cancer Institute Okayama University Medical School
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Tobina Takuro
Graduate School of Education, Hokkaido University
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Shindo Munehoro
Faculty of Sports and Health Science, Fukuoka University
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