Relationship between Angiotensin Converting Enzyme Gene I/D Polymorphism and Muscle Strength in Elderly

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概要

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• Previous studies have indicated that the Angiotensin I converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism could influence human physical performance. Furthermore, a study has suggested that ACE inhibitor treatment might decrease long-term decline in muscle strength in elderly women. Thus we hypothesized that the I allele of ACE gene I/D polymorphism, which relates to lower ACE activity, might be associated with slow-decline of muscle strength in the elderly. One hundred ninety elderly people aged 72 were recruited for this study. We assessed isometric knee extension strength, leg extension power and grip strength every year for 4 years. In the preliminary measurements, physical characteristics and muscle strength were not significantly different among three genotypes. Age-related changes of the isometric knee extension, leg extension power, grip strength were similar among three genotypes. The results of this investigation suggest that ACE gene I/D polymorphism does not affect age-related change of muscle strength in the elderly.

著者

• Saku Keijiro

  Fukuoka University

• Shindo Munehiro

  Faculty Of Sports And Health Fukuoka University

• Zhang Bo

  Fukuoka University

• KIMURA Yasuo

  Faculty of Agriculture, Tottori University

• Kiyonaga Akira

  Faculty Of Sports And Health Fukuoka University

• Yoshitake Yutaka

  National Institute Of Fitness And Sports In Kanoya

• Tanaka Hiroaki

  National Agricultural Research Center for Western Region.

• Miyazaki Hideo

  Graduate School of Medical and Dental Sciences, Niigata University

• Kiyonaga Akira

  Faculty of Sports and Health Science, Fukuoka University

• Tobina Takuro

  Graduate School of Education, Hokkaido University

• Ayabe Makoto

  Graduate school of Education, Hokkaido University

• Ishii Kojiro

  Graduate School of Education, Hokkaido University

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