Enzymatic Synthesis of Dehydroderivatives from Proline-Containing Cyclic Dipeptides and Their Effects toward Cell Division
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概要
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We have previously isolated cyclo(L-Pro-L-Tyr) and cyclo(L-Phe-L-Pro) from an actinomycete by a novel enzymatic conversion-guided method. Their tetradehydro derivatives, cyclo(ΔPro-ΔTyr) and cyclo(ΔPhe-ΔPro), were enzymatically prepared. Neither of them inhibited cell division, in contrast to other tetradehydro cyclic dipeptides prepared previously. This result suggests that an NH proton in a diketopiperazine ring and/or conformation of the compound are important for the activity.
- 社団法人 日本農芸化学会の論文
著者
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KANZAKI HIROSHI
Laboratory of Bioresources Chemistry, Faculty of Agriculture, Okayama University
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NITODA TERUHIKO
Laboratory of Bioresources Chemistry, Faculty of Agriculture, Okayama University
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IKEDA Banri
Laboratory of Bioresources Chemistry, Faculty of Agriculture, Okayama University
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Ikeda Banri
Laboratory Of Bioresources Chemistry Graduate School Of Natural Science And Technology Okayama Unive
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ARUNRATTIYAKORN Panarat
Laboratory of Bioresources Chemistry, Graduate School of Natural Science and Technology, Okayama Uni
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