Effects of interferon-τ on cattle persistently infected with bovine viral diarrhea virus

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In this study, the antiviral effects of bovine interferon-τ (boIFN-τ) on bovine viral diarrhea virus (BVDV) were examined in vitro and in vivo. In the in vitro experiments, the replication of cytopathic and non-cytopathic BVDV was inhibited in the bovine cells treated with boIFN-τ. The replication of BVDV was completely suppressed by boIFN-τ at a concentration higher than 10^[2] U/ml. In order to examine the effect of boIFN-τ on virus propagation in cattle persistently infected (PI) with non-cytopathic BVDV, boIFN-τ was subcutaneously administered to PI cattle at 10^[5] U/kg or 10^[6] U/kg body weight 5 times per week for 2 weeks. No physical abnormality such as depression was observed in the cattle during the experiment. The mean BVDV titers in the serum of the PI cattle decreased slightly during the boIFN-τ administration period with the dose of 10^[6] U/kg. However, the BVDV titers in the serum returned to the pre-administration level after the final boIFN-τ administration. These results suggest that boIFN-τ demonstrates an anti-BVDV effect, reducing the BVDV level in serum transiently when injected into PI cattle.