Linkage and association analyses of the osteoprotegerin gene locus with human osteoporosis

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概要

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• This is the author-created version of Springer, Ohmori, H. ; Makita, Y. ; Funamizu, M. ; Hirooka, K. ; Hosoi, T. ; Orimo, H. ; Suzuki, T. ; Ikari, K. ; Nakajima, T. ; Inoue, I. ; Hata, A., JOURNAL OF HUMAN GENETICS, 47(8), 2002, 400-406. The original publication is available at www.springerlink.com.authorOsteoprotegerin (OPG), a secreted glycoprotein and a member of the TNF receptor superfamily, is considered to play an important role in the regulation of bone resorption through modifying osteoclast differentiation. Overexpression of OPG in mice has been reported to result in osteopetrosis, whereas targeted disruption of OPG in mice has been associated with osteoporosis. Accordingly, OPG could be a strong candidate gene for susceptibility of human osteoporosis. Here, we analyzed whether OPG is involved in the etiology of osteoporosis using both linkage and association analyses. We recruited 164 sib pairs in Gunma prefecture, which is located in the central part of Honshu (mainland Japan), for a linkage study, and 394 postmenopausal women in Akita prefecture, which is in the northern part of Honshu, for an association study. We identified two microsatellite polymorphisms for a linkage study, and six single nucleotide polymorphisms (SNPs) for an association study in the OPG region. Although, no evidence of significant linkage between OPG and osteoporosis was found, a possible association of one SNP, which locates in the promoter region of the gene, was identified. Haplotype analysis with six SNPs revealed that four major haplotypes account for 71% of the alleles in the Japanese population.

• Springer-Verlag Tokyoの論文
• 2002-08-01

著者

• Makita Yoshio

  Department Of Pediatrics Asahikawa Medical College

• Makita Yoshio

  Department Of Public Health Asahikawa Medical College

• NAKAJIMA Toshiaki

  Division of Genetic Diagnosis, The Institute of Medical Science, The University of Tokyo

• Ikari Katsunori

  Division Of Genetic Diagnosis Institute Of Medical Science University Of Tokyo

• Inoue Ituro

  Division Of Genetic Diagnosis Institute Of Medical Science The University Of Tokyo

• Hosoi Takayuki

  Tokyo Metropolitan Geriatric Hospital

• Hata Akira

  Department Of Public Health Asahikawa Medical College

• SUZUKI Takao

  Tokyo Metropolitan Institute of Gerontology

• Orimo H

  Tokyo Metropolitan Geriatric Hospital

• Orimo Hajime

  Tokyo Metropolitan Geriatric Hospital

• Hirooka Kenzou

  Department Of Public Health Asahikawa Medical College

• Hirooka Kenzou

  Department Of Economics Faculty Of Economics Asahikawa University

• Ohmori Hiroyuki

  Department Of Public Health Asahikawa Medical College

• Ohmori Hiroyuki

  Department Of Neurology Graduate School Of Medical Science Kumamoto University

• Ikari Katsunori

  Division Of Cardiology Sakurabashi Watanabe Hospital

• Nakajima T

  Division Of Environmental Medicine Department Of Preventive Medicine School Of Medicine Shinshu Univ

• Funamizu Makiko

  Department Of Public Health Asahikawa Medical College

• Hata A

  Department Of Public Health Asahikawa Medical College

• Nakajima Toshiaki

  Division Of Genetic Diagnosis The Institute Of Medical Science The University Of Tokyo

• Nakajima Toshiaki

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Suzuki T

  Division Of Food Chemistry Osaka Prefectural Institute Of Public Health

• Nakajima Toshiaki

  Division Of Genetic Diagnosis Institute Of Medical Science University Of Tokyo

• Nakajima Toshiaki

  Division Of Cardiovascular Surgery Nippon Medical School

• Funamizu M

  Department of Public Health, Asahikawa Medical College

• Hirooka K

  Tokyo Metropolitan Geriatric Hospital

• Hosoi T

  Tokyo Metropolitan Geriatric Hospital

• Ikari K

  Division of Genetic Diagnosis, Institute of Medical Science, University of Tokyo

• Inoue I

  Department of Public Health, Asahikawa Medical College

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