The synthetic analogue of mycoplasmal lipoprotein FSL-1 induces dendritic cell maturation through
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概要
- 論文の詳細を見る
GM-CSF-differentiated bone marrow-derived DCs (BMDCs) were stimulated with FSL-1 or E.coli LPS. FSL-1 induced the production of TNF-α and IL-12 by C57BL/6-derived BMDCs but not by BMDCs from Toll-like receptor 2-deficient (TLR2-/-) mice, whereas LPS induced the production of TNF-α and IL-12 by BMDCs derived from either type of mice. FSL-1 did not induce production of IL-10 by BMDCs from either type of mice, whereas LPS induced small amounts of IL-10 by BMDCs from both types of mice. FSL-1 upregulated the expression of CD80, CD86 and the MHC class II molecule IAb in both dose- and time-dependent manners on the surfaces of C57BL/6-derived BMDCs but not on the surface of TLR2-/--derived BMDCs, whereas LPS upregulated the expression of them on the surfaces of BMDCs from both types of mice. The expression of CD11c on the surfaces of C57BL/6-derived BMDCs was upregulated by stimulation with both FSL-1 and LPS up to 12 h and then the expression was downregulated.The results suggest that FSL-1 has activity to accelerate maturation of BMDCs and that the activity of FSL-1 is mediated by TLR2.
- Blackwellの論文
著者
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Shibata K
Department Of Oral Pathobiological Science Hokkaido University Graduate School Of Dental Medicine
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Shibata Ken-ichiro
Division Of Oral Molecular Microbiology Department Of Oral Pathobiological Science Hokkaido Universi
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Kiura Kazuto
Division Of Oral Molecular Microbiology Department Of Oral Pathobiological Science Hokkaido Universi
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Shibata Ken-ichiro
Division Of Oral Molecular Microbiology Department Of Oral Pathobiological Science Hokkaido Universi
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