シスプラチン誘導体(DWA 2114R)による再燃前立腺癌の治療

概要

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1)骨転移を有する内分泌療法後の再燃前立腺癌11例に対し,シスプラチン誘導体DWA 2114Rを用いて化学療法を行った.2)総合臨床効果は,PR 3例,NC 4例,PD 4例であった.3) 6例に疼痛の有意な改善がえられ,うち5例では疼痛の消失により外来治療が可能となったDWA2114R (DWA) is a new derivative of platin compounds. Eleven patients with rapidly progressive, endocrine-resistant stage D carcinoma of the prostate were treated with infusion of DWA (800-1,000 mg/m2) every 3 to 4 weeks. A partial objective response was observed in 3 of 11 patients (27%). This response lasted from 5 to 11 months with an average of 7.7 months. Six patients (55%) had a significant decrease or disappearance of bone pain and five became ambulatory and asymptomatic. Four patients (36%) showed no change, and four patients (36%) did not respond to the treatment and showed progression of their disease. There were no patients with severe leukopenia (less than 1,000/mm3). No significant renal toxicity was observed in any of the patients and gastrointestinal toxicity was tolerable. DWA appears to be an effective drug available for the treatment of endocrine-resistant advanced carcinoma of the prostate.