ウコッケイのhyper melanizationにおけるエンドセリン・エンドセリン受容体の関与

概要

論文の詳細を見る
Silky is known as a unique chicken expressing heavy melanization inalmost all internal organs, but the mechanisms of the hyper pigmentation havenot been clearly understood. Previous studies have shown that endothelin 3（ ET3）,one of endothelines （ETs）, plays an important role for proliferation anddifferentiation of cultured chicken melanocytes. We investigated the amounts andexpressions of transcripts in both ET3 and its receptor EDNRB2 in several chickenlines including Black Silky. Consequently, the ET3 and EDNRB2 transcripts werespecifically expressed in cultured fibroblasts and melanocytes, respectively. Theamounts of both ET3 and EDNRB2 transcripts in the cultured cells and tissuesfrom Silky were slightly higher than other lines. These results suggest that upregulated ET3 and EDNRB2 possibly effect to internal hyper pigmentation in theearly embryonic phase of Silky.