グアバ(Psidium guajava L.)の研究(第1報) : グアバ葉の抗糖尿病薬理活性とその有効成分の研究(その1)

概要

論文の詳細を見る
Studies were conducted on anti-diabetic effect of a 50% ethanolic extract (G-ext) from leaves of Psidium guajava L., which had been used in Japan and the subtropical zones as a remedy for diabetes. G-ext (200 mg/kg, p.o.) was found to inhibit the increase in the plasma level of sugar but not the decrease in the plasma level of insulin in alloxan-induced diabetic rats. In the glucose tolerance test, G-ext was shown to inhibit the increase in plasma sugar level in such diabetic rats at a dose of 200 mg/kg, p.o. A n-BuOH soluble fraction prepared from G-ext also inhibited the increase in plasma sugar level in alloxan-induced diabetic rats (25 or 100 mg/kg, p.o.). In the glucose tolerance test, this fraction inhibited the increase in plasma sugar level in alloxan-induced diabetic rats (100 mg/kg). For examining the mechanism of the action, such preparations were examined for their insulin-like or antilipolytic activity. G-ext, the n-BuOH-soluble fraction and water soluble fraction were all found to suppress adrenaline-induced lipolysis in fat cells from rat epididymal adipose tissues. By an assay using adrenaline-induced lipolysis, isostrictinin, strictinin and pedunculagin were isolated from the n-BuOH soluble fraction of G-ext.
日本生薬学会の論文
1985-12-20