生薬の基源, 修治, 品質に関する研究(第3報)漢薬・朮の実験的胃潰瘍に対する予防効果の薬理学的評価その3 西北蒼朮(Atractylodes lancea var. chinensis)の胃液分泌に及ぼす影響について

概要

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"Zhu", dried rhizomes of Atractylodes species has been used for the treatment of indigestion and stomachache as stomachic in traditional Chinese system of medicine. In previous papers, we reported that among various kinds of "Zhu", 50% methanolic extracts of Atractylodes lancea and Atractylodes lancea var. chinensis showed strong inhibitory activity on most experimental ulceration, while those of Atractylodes ovata and Atractylodes japonica produced a significant inhibition on stress-induced ulceration in rats. In order to explore the mode of anti-ulcerogenic activity of 50% methanolic extract of Atractylodes lancea var. chinensis (AC), in the present study, the inhibitory activity of extract on gastric acid secretion in perfused stomach preparation, on gastric secretion in adrenalectomized rats and cooperative activity with steroidal hormone were investigated. Consequently, it was suggested that the anti-ulcerogenic action of AC was closely related to the movement of steroidal hormone in the plasma.
社団法人日本薬学会の論文
1985-10-25