重症敗血症あるいは敗血症性ショック症例におけるplasminogen activator inhibitor-1の動態(<特集>21世紀のアフェレシス-作用機序と臨床効果のエビデンス)

概要

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We examined changes in plasminogen activator inhibitor-1(PAI-1)in patients with severe sepsis or septic shock who had been treated with adsorption of endotoxin by polymyxin B immobilized fiber(PMX-DHP). An increase in PAI-1 values observed in the group that exhibited high endotoxin values raised these values to more than twice as much as those in the group that exhibited normal endotoxin values. PAI-1 values tended to decrease in both groups immediately after PMX-DHP therapy, and the rate of decrease was larger than in the high endotoxin group after 24 h. The survival rate was 73% in a high endotoxin group and 75% in a normal endotoxin group. The determination of PAI-1 may be a useful clinical parameter for predicting PMX efficacy.
日本アフェレシス学会の論文
2001-02-28