10. 両親媒化キサンテン色素の腫瘍集積性およびキャビテーション閾値低下効果

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Acoustic cavitation is a typical non-thermal phenomenon induced in liquids and biotissues exposed to ultrasound. Its effects may be useful for therapeutic purposes if properly controlled. Techniques for promotion and suppression of acoustic cavitation will provide such controlling methods. As chemicals for reducing cavitation threshold, we previously reported that certain photosensitizers, such as rose bengal, in xanthene family are effective both in water and mouse liver. One of our research targets is applying these chemicals to cancer treatment. However, such xanthenes have poor affinities with tumor tissues. Some of porphyrins, another photosensitizer family, are known to show high affinities with tumor tissues. It has been proposed that their amphiphilicity is a factor int these high affinities. As an approach to obtain xanthenes with improved affinities with tumor tissues, we synthesized amphiphilic rose bengal derivatives. Three kinds of derivatives with incorporated alkyl groups (carbon numbers: 7-15) as the lipophilic group and carboxilic group as the hydrophilic group were synthesized. One of the families in synthesized derivatives was found to be amphiphilic and they reduced cavitation threshold in water about as much as rose bengal do. The derivatives also showed significantly increased affinities with subcutaneously-implanted murine tumor tissues.
日本ソノケミストリー学会の論文