8. キサンテン系色素によるin vivoおよびin vitroでのキャビテーション閾値の低下

概要

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For therapeutic application of cavitational effects, it is very important to obtain the effects at low acoustic intensity. We are approaching in two ways. One is finding chemicals which lowers cavitation threshold and the other is optimized ultrasonic waveforms for inducing cavitation. We previously reported that organic compounds with multiple chlorine can lower cavitation thresh- old in water. Unfortunately, such chemicals require too high concentration to be administrated into human bodies. This time we investigated the effect of xanthens, a dye family with multiple halogen atoms, for reducing cavitation threshold in both water and living mice livers. In the presence of Erythrosine or Rose bengal, cavitation thresholds in water and mice livers were about five times and ten times smaller than in the absence of the xantenes, respectively.
日本ソノケミストリー学会の論文
1997-10-01