23. タンパクと共有結合可能なキサンテン色素のキャビテーション誘導能

概要

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Recently, we found that Rose bengal(RB), one of the most efficient sensitizer for photo-oxidation, can reduce the threshold for sonochemically active cavitation. We have found that RB reduces cavitation threshold in mice livers for several hours after administration although most of RB is eliminated within 30 minutes (Fig3). This result suggested that the effect of RB is induced with some interaction with tissues. We investigated the effect of RB derivatives with functional groups reactive with thiol group, which may increasethe binding of RB with proteins. Among functional groups investigated, a derivative with iodoacetamide was most effectively reduced cavitation threshold in mice livers (Fig4). This result indicated some interaction of RB with proteins (amino acids) may be related to the effect of RB in reducing cavitation threshold.
日本ソノケミストリー学会の論文