カーボンナノチューブによる温熱デバイスの構築と骨再生補助基材としての有用性の検討

概要

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The aim of the present study is to construct the heat shock device using carbon nanotubes (CNT) and promote to bone reconstruction and remodeling using the devise. To apply heat shock stimulation to the injurious tissues and cells we firstly fabricated the alginate disk containing CNT. Secondly, we composed of the device with CNT disk and near-infrared light source. The heat shock device rapidly increased to set point of temperature in culture medium and it is easy to be maintained the temperature. Thus, we used the heat sock device and examined about the effects of heat shock on osteogenesis in mouse osteoblasts, MC3T3-E1. The culture dishes with cells were packed in 5% CO_2 and incubated 37℃. The heat shock stimulation using the CNT device promoted the osteogenesis together with upregulation of differentiation gene such as alkaline phosphatase, runx2 and osterix compared to no stimulation in mouse osteoblasts MC3T3-E1. In conclusion, the heat shock device using CNT is useful to bone reconstruction via osteogenesis.
2012-12-06