P-19 薬剤徐放性コラーゲン基材の調製 : 架橋法による架橋効率の比較(溶出・滅菌・消毒・毒性,一般講演(ポスター発表),第58回日本歯科理工学会学術講演会)

概要

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Aiming to develop a bioabsorbing scaffold material from type I collagen, crosslinked spongy collagen was prepared using either glutaraldehyde (GA) or carbodiimide (EDC)as crosslinker, to which drug-releasing function was expected. Both the concentration of crosslinker and the reaction time ware varied to prepare the spongy collagen with different degree of crosslinking. TNBS method was used to estimate and quantify the crosslinking rate. While the crosslinking rate increased with the crosslinker concentration and the reaction time, it was not reflected to the appearance observed by SEM. Since GA is unfavorable to the organ, EDC may be a good alternative as the crosslinker.
2011-09-25