P-37 バイオフィルム構成多糖の粘弾性に及ぼす抗菌性界面活性剤の影響(臨床応用,一般講演(ポスター発表),第56回日本歯科理工学会学術講演会)

概要

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High viscosity of aqueous solution of hyaluronic acid (HyA), an important constituent polysaccharide of biofilms, was drastically lowered and the solution became highly turbid by addition of cationic antibacterial surfactants as cetylpyridinium chloride (CPC). While CPC-free HyA molecules are extended by the internal charge repulsion and intermolecular entanglement causes high viscosity of the solution, CPC cations would electrostatically bind to the negatively charged HyA chains and neutralize them, which in turn may cause the shrinking of HyA polymer and lowers the viscosity. Hydrophobic interaction of the tails of bound CPC should enhance the aggregation as perceived by the strong turbidity.
2010-09-20