P-49 バイオフィルム関連高分子マトリックス中の薬剤透過性の定量評価の試み(細胞・生体組織・インプラント・滅菌・消毒,一般講演(ポスター発表),第58回日本歯科理工学会学術講演会)

概要

論文の詳細を見る
Aiming to quantitatively evaluate the permeability of an antimicrobial AF through the concentrated solution of hyaluronic acid, as a model of oral biofilm, diffusion efficiency of AF was investigated by monitoring its concentration change in the HyA solutions of various viscosity. The viscosity was higher at larger HyA concentration, lower at acidic condition, lower in the presence of cationic surfactants. It became clear that the diffusion efficiency was enhanced in the HyA solution with lower viscosity. Thus, it was suggested that the permeability of antimicrobials would be affected by the viscosity of the biofilm through which they diffuse. Dilution of the polysaccharide layer component by washing, strongly acidic condition, or addition of cationic surfactants may lower the viscosity of the biofilm and hence help the effective delivery of antimicrobials.
2011-09-25