ブラジル産プロポリスのチロシナーゼ阻害物質

概要

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The tyrosinase inhibitiory activity was examined on the main constituents of Brazilian propolis. Artepillin C, (E)-3-prenyl-4-(dhydrocinnamoyloxy)cinnamic acid, (E)-3-(2,2-dimethyl-8-prenyl-2H-benzopyran-6-yl)-2-propenoic acid, kaempferol and kaempferide showed potent inhibitory activities, and had higher activities than those known for kojic acid or ascorbic acid as tyrosinase inhibitors. The type of inhibition by artepillin C with respect to L-tyrosine as substrate was characteristically noncompetitive. For the structure-activity relationships, the tyrosinase inhibitory activity tended to increase with the presence of the hydroxyl or the methoxyl group at position 4 of the aromatic ring. Furthermore addition of the prenyl group or the presence of the hydroxy group at position 7 of the flavonoid may play an important role for increasing the inhibition of tyrosinase. Brazilian propolis show lower activity than the propolis of other countries [China, Japan, Australia, Ukraine, Hungary, Uruguay]. It was suggested that the propolis of other countries contained various flavonoids which were responsible for the inhibitiory activity.
2001-06-20