抗酸化作用を指標にした動物性生薬及び食材の抗疲労作用

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The anti fatigue effects of 50% ethanol extracts from Mamushi (dried whole body of Agkistrodon blomhoffii blomhoffii, Mam-ext),IIampi (dried head, bone and muscle of Agkistrodon blomhoffii blomhoffii, Ham-ext), Kaiba (Hippocampus japonicus, Kab-ext), Aodaisho (dried whole body of Elaphe climacophora, Aod-ext) and Unagi (dried whole body of Anguilla japonica, Una-ext) were investigated by monitoring the antioxidative effects. At successive doses of 500 mg/kg/d for 3 days Mam-ext, Ham-ext and Kab-ext significantly decreased the liver lipid peroxide (TBARS) content in mice and Aod-ext and Una-ext were weakly. Mam-ext, Ham-ext and Kab-ext inhibited the elevation of TBARS level induced by H_2O_2 and Fe^<2+> in hepatic homogenate and microsome. Mam-ext, Ham-ext and Kab-ext also prolonged the swimming time of mice loaded on the tail with a steel washer of approximately 2 % of their body weight, Aod-ext and Una-ext had no effect. From these results, we consider that the antioxidative effect on the liver TBARS content may be a useful maker for the study of anti-fatigue effects.
1998-04-20