生薬・マムシの薬理活性研究(第6報) : 肝カタラーゼ活性に及ぼす50%エタノールエキスの影響

概要

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This study was performed in order to elucidate the effect of "Mamushi," a Japanese folk medicine, on the hepatic catalase activity in acute weight-loaded forced swimming (AWLFS)-treated rats. A 50% ethanol extract ([M])from dried whole body of Agkistrodon blomhoffii blomhoffii Bom. inhibited the decreases of catalase activity and tissue blood flow and the increase of lipid peroxide (TBARS) content in the liver of AWLFS rats. In hepatic aorta- and veins-ligated rats, [M] inhibited the lowering of catalase activity, but had no effect on the decreasing of blood flow. [M] inhibited the production of TBARS induced by H_2O_2 and Fe^<2+>, both in a hepatic hornogenate and a hepatic microsome fraction. These results indicate that Mamushi reduces oxidative stress, and that it may function as an agent for the treatment of fatigue. The mode of action is partially attributable to the stimulation of the hepatic catalase activity and its radical-scavenger-like action.
1997-10-20