修治附子の抗侵害受容作用機序 : オピオイド受容体の関与

概要

論文の詳細を見る
The effect of naloxone, an opiate receptor antagonist, on an antinociceptive action of processed Aconiti tuber (TJ-3022, 1 g/kg, p.o.) was compared with its effect on morphine (4 mg/kg, p.o.)-induced antinociception in mice. Naloxone (4 mg/kg, i.p.) attenuated the antinociceptive activity of morphine dramatically, but it antagonized the increase of nociceptive threshold in TJ-3022-treated animals only partially even when naloxone was injected intraperitoneally at a dose of 10 mg/kg. When injected intrathecally, naloxone (2-20 μg/mouse) showed an inhibitory action on the TJ-3022 antinociception in a dose-dependent manner. However, the amount of naloxone required for the inhibition of the antinociceptive response elicited by TJ-3022 was 10-20 times that of morphine. These results suggest that a part of the TJ-3022 antinociceptive activity is mediated by the opioid receptors in the spinal cord, but not related to the μ-receptor subtype.
日本生薬学会の論文
1997-08-20