OS1013 外力に対するGタンパク連結型受容体のコンホメーション変化の分子動力学解析(生体と材料力学,オーガナイズドセッション)

概要

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Changes in the conformation of a bovine rhodopsin, ich is a member of G-protein cowled receptor (GPCR) family, induced by external forces were simulated using a molecular dynamics simulation vith a computational software (NAMD 2.6, University of Illinois). Two molecular models were constructed; one is for a single thodopsin (modelR) and the other for the rhodopsin embedded into a lipid bilayer memlxane (model RM). The external forces were applied to the extracellular domain of the rhodopsin. As a result of simulation, the large conformation changes were exhibited near the extracellular domaiii In seven lransmemlxane α-helices the changes in both length and angle were the largest in the fourth α-helix, indicating that the fourth α-helix is the most affected by the external forces.
一般社団法人日本機械学会の論文
2009-07-24