745 脊髄組織の粘弾性変形と流動電位の関係(S01-1 細胞と組織のバイオメカニクス(1)-ミクロからマクロまで-,21世紀地球環境革命の機械工学:人・マイクロナノ・エネルギー・環境)

概要

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The purpose of this study is the elucidation of electro-mechanical response of spinal cord tissue. Spinal cord tissue is composed of white matter, gray matter, spinal meninges and water. The tissue has triphasic construction consisting of solid phase, fluid phase and electric reactions. Solid phase contains negative charged proteoglycan which enhance swelling pressure and exerts an influence on the tissue behavior. On the other hand, strain increases fixed charge density relating to electric potential gradient and streaming potential. We conducted the confined compression tests on spinal code specimens cut out from both white matter and gray matter. Ag/AgCl electrodes were used to measure the electric potential change on each specimen deforming in physiological saline. The streaming potential measurements were performed under compression, cyclic loading and ramp/stress-relaxation displacements. The measured potentials were correlated well with strain and stress. In the compression/stress-relaxation test, linear relation was confirmed between the stress and streaming potential with constant value of electrokinetic coefficient ke used in triphasic theory. Streaming potential was detected in each loading condition and the value varied in different tissue.
社団法人日本機械学会の論文
2008-08-02