経尿道的前立腺切除術における経口抗菌剤予防的投与の有用性についての検討

概要

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We devided infections following transurethral resection of the prostate (TUR-P) into postoperative acute phase infections occurring within 7 days of the operation and healing phase infections occuring from the 8th day postoperatively, and studied the prophylactic effect of oral ofloxacin (OFLX) on these infections. The subjects were 47 patients who underwent TUR-P for prostatic hypertrophy. In postoperative week 1, OFLX was administered at a dose of 200～400 mg/day for patients without preoperative urinary tract infection (UTI) or 600 mg/day for patients with preoperative UTI. Subsequently, 100 mg of OFLX was administered once before retiring in both groups. Infection was defined on the basis of a temperature of at least 38.0℃ and the detection of UTI. Postoperative acute infections ocurred in 12 out of 47 patients (26%). Preoperative UTI, diabetes, and long-term postoperative catheterization were clearly identified as risk factors. Healing phase infections showed a relatively low incidence of 13% (4/31 patients), suggesting that administration of a small dose of OFLX before retiring was useful.
東京女子医科大学の論文
1996-03-25