無症候性Brugada型心電図における心電図学的特徴と長期予後についての検討 : 連続42,726例の住民検診からの検討

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Brugada syndrome is characterized by a unique ECG pattern (Brugada-type ECG, or B-type ECG) and is a subgroup of idiopatbic ventricular fibrillation. The aim of this study was to investigate the prevalence of a B-type ECG among healthy subjects and to assess interval change and survival prognosis for those identified with asymptomatic B-type ECG. A total of 42,726 consecutive healthy subjects (age: 59 ± 14, male/female ratio: 14,887/27,839) were examined using 12-lead ECGs taken during local public health check-ups in Japan in 1997. B-type ECG was defined as ST-segment elevation with either coved or saddle-back type elevation pattern (≧0.1 mV) in V1 and V2 in this study. The study found that B-type ECG was prevalent in 0.41 % of the total subjects. Males displayed a higher rate (0.90%), than females (0.15%). ST-segment elevation was significantly greater in V2 than in V1. The spontaneous interval changes in the ST-segment were also more commonly observed in V2 than in V1. After 103 ± 5 months of follow-up, 95% of the B-type ECG subjects (166 cases) were still alive. Five percent (9 cases) were dead, but no sudden death cases were observed. The long-term prognosis for asymptomatic B-type ECG subjects identified by the public health check-up in Japan was benign.
東京女子医科大学の論文