洞結節細胞における伸展活性化チャネルの役割(イオンチャネルと病態,シンポジウム,<特集>東京女子医科大学学会第62回総会)

概要

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Stretch-activated current was studied in rabbit sino-atrial node cells using the whole-cell patch clamp method. With continuous application of positive pressure through the patch electrode, the cell was inflated and the membrane conductance was increased. The stretch-activated current showed time-independent and outward rectifying properties and the current was sensitively reduced by the Cl channel blockers, such as SITS, DNDS or 9-AC. The reversal potential of stretch-activated current was well explained by the equilibrium potential of Cl. These findings indicate that the stretch-activated current is Cl selective, and the results suggested that the stretch-activated Cl current may contribute to the positive chronotropic effect during mechanical stimulation in sino-atrial node cells.
東京女子医科大学の論文
1997-04-25