Effects of Glutathione Depletion on Hypoxia-induced Erythropoietin Production in Rats
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概要
- 論文の詳細を見る
In vitro studies have indicated that reactive oxygen species modifying cellular redox status are involved in hypoxia-induced erythropoietin (EPO) production. However, the effects of redox balance on hypoxia-induced EPO production in vivo are still not fully understood. To investigate the effect of the change in cellular redox status on EPO generation, we determined whether glutathione (GSH) depletion has a significant influence on hypoxia-induced EPO production in rats. For the inhibition of GSH synthesis, DL-buthionine-[S,R]-sulfoximine (BSO) was employed by intraperitoneal injection. Twenty male rats were assigned to one of four experimental groups: (1) normoxic placebo, (2) normoxic BSO, (3) hypoxic placebo, and (4) hypoxic BSO. Hypoxic groups were exposed to a simulated normobaric hypoxic conditio (4,500m above sea level) for 12 hours. BSO treatment resulted in a significant depletion of total GSH levels in kidney and plasma in both conditions. However, the hypoxia-induced elevation in serum EPO concentration was not completely affected by the inhibition of GSH synthesis. These data demonstrate that GSH depletion in the kidney is not involved in the increase in serum EPO concentration in response to systemic hypoxia. It is also conceivable that the cellular redox changes could not function as a primary regulator of hypoxia-induced renal erythropoietin formation in vivo.
著者
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ANDO Daisuke
Department of Physical Education, National Defense Academy
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YAMAGATA Zentaro
Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, Univer
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KOYAMA Katsuhiro
Faculty of Education and Human Sciences, University of Yamanashi
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YAMAKITA Mitsuya
Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, Univer
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Ando Daisuke
Department Of Physical Education National Defense Academy
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Ando Daisuke
Faculty Of Education And Human Sciences University Of Yamanashi
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Ando Daisuke
Laboratory Of Biodiversity Science School Of Agriculture And Life Sciences University Of Tokyo
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Yamagata Zentaro
Department Of Health Sciences Interdisciplinary Graduate School Of Medicine And Engineering Universi
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Yamakita Mitsuya
Department Of Health Sciences Interdisciplinary Graduate School Of Medicine And Engineering Universi
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Koyama Katsuhiro
Faculty Of Education And Human Sciences University Of Yamanashi
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Yamagata Zentaro
Department Of Health Sciences Faculty Of Medicine School Of Medicine University Of Yamanashi
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Yamagata Zentaro
Department Of Health Sciences Interdisciplinary Graduate School Of Medicine And Engineering Universi
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安藤 大輔
National Defense Academy
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