12. 直立円筒凍結乾燥における凍層形成と未凍溶液部の濃縮現象(平成4年度第38回凍結及び乾燥研究会研究報告)

概要

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In a process of freeze-drying of liquid material by the use of vertical tubes, it is important that the solute concentration upon thawing of the frozen layer C_f should be equal to that of the non-frozen liquid removed away from the tubes C_I when desired amount of the frozen layer is formed. Phenomena taking place in the frozen layer formation with several aqueous solutions, mostly sucrose and dextrin, were analysed in this study. The influences of initial solute concentration C_o, freezing rate (cooling brine temperature T_h and percentage of the frozen layer to the amount of liquid poured into a tube β on C_f and C_1 have been studied experimentally. In each case for C_o=10, 20, and 30 wt % of sucrose, the difference between C_f and C_1 was observed only under slow freezing conditions, i.e. growth velocities of a couple of centimeters per hour or less (T_h≧-20℃). While for dextrin solutions, any concentration changes did not occur. Availability of "Multi-Stage Frozen Layer Formation" was confirmed in this study.
低温生物工学会の論文
1992-10-20