ハツカネズミのワルファリン感受性と死亡遅延

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To examine the susceptibility of the wild house mice (Mus musculus L.) to warfarin, a no-choice feeding test with 0.025% warfarin bait was carried out using the house mice caught in Japan. Furthermore, the same test as mentioned above was conducted using ICR strain mice and roof rats, Rattus rattus. As a whole, 84 mice were tested for fixed periods ranging between 3 and 38 days. All mice excluding two died within two weeks. The lowest fatal dosage was 86.3mg/kg in 3 days by a female from Sagamihara and the highest fatal dosage was 1,396.0mg/kg by a male from Chiba. Over 97.6% of all mice which examind this time showed high susceptibilities to the warfarin. We found that both introduced subspecies, M. musculus castaneus from Chiba harbors and M. musculus domesticus from Ogasawara island, showed a tendency of higher values of lethal dosages and days than of M. musculus musculus from Funabashi and other inland areas. On the other hand, F_1 and F_2, which were descendant between ICR mice and survivors eaten 0.025% warfarin bait during 12 days, did not show any resistance to 0.025% warfarin bait. House mice fed 0.025% warfarin bait of 2 times as much as that of roof rats, Rattus rattus on the first day in the feeding test for certain days and the lethal dose in the former were 1.69-3.04 times as much as that of the latter, which showed the susceptibility for 0.025% warfarin bait. Two house mice from Chiba harbors and Ogasawara island reduced consumption of the poisonous bait two to five days during the test, which was supposed to cause delay of time to death.
日本ペストロジー学会の論文
1999-05-31

ハツカネズミのワルファリン感受性と死亡遅延

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