ワルファリン抵抗性および感受性クマネズミに対するクマテトラリルの効力

概要

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The authors discussed the effect of bait formulation containing coumatetralyl of 0.025% and 0.0375% on warfarin-resistant and susceptible roof rats, Rattus rattus, and wild roof rats caught in Shinjuku Ward, Tokyo, Japan. When 0.025% and 0.0375% toxic baits of coumatetralyl were given respectively to the warfarin-resistant roof rat, there was a significant difference (P<0.05) in mortality and bait intake between the two test groups. With an increase in coumatetralyl concentration, the effect was substantial even to the warfarin-resistant group. It was evident that coumatetralyl exceed efficacy than warfarin at the same concentration. When 0.025% and 0.0375% toxic baits of coumatetralyl were given to the warfarin-susceptible group, there was no significant difference in mortality and bait intake. It was not essential to increase the coumatetralyl concentration in case of the warfarin-susceptible roof rat and coumatetralyl was effective at the low concentration. When 0.025% toxic bait of coumatetralyl was given to the wild rats caught in Shinjuku Ward, Tokyo, the results were similar to that of the 0.025% test group of warfarin-resistant rat in lethal feeding period and bait intake. It was proved that those rats exhibited high resistance to warfarin.
2004-09-15