ワルファリン抵抗性と感受性クマネズミに対するジフェチアロン製剤の効力

概要

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The efficacy of toxic bait, which includes 0.0025% difethialone: [(bromo-4'-[biphenyl-1-1']-yl-4)3-tetrahydro-1,2,3,4-naphthyl-1] 3-hydroxy-4 2H-1 benzothiopyrane-one, was tested against warfarin-resistant and susceptible roof rats (Rattus rattus). When 0.0025% difethialone baits were given to the warfarinresistant roof rats, 5 of 12 warfarin-resistant rats were killed after eating a.i. (active ingredient) 1.8mg/kg in average for 24 hours. After eating 4.7mg/kg bait in average for 2 days, 11 of 12 rats were killed. Nine of 12 rats were killed 3 days after eating a.i. 6.9mg/kg. All rats tested died within 4 days after eating a.i. 10.4mg/kg (n=12). On the other hand, when 0.0025% difethialone baits were given to the warfarin-susceptible roof rats (n=12), all rats were killed after eating a.i. 1.7mg/kg in average for 24 hours exposure.
日本衛生動物学会の論文
2006-12-15