Mongolian plant extracts with potential glucose absorption inhibiting effects in rats

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The present study was performed to investigate the acute effect of plant extracts on glucose absorption in rats. Thirty aqueous dried plant extracts that have been commonly used in the Mongolian traditional medicine as antidiabetic, anti-inflammatory, immunomodulant, and hypotensive were selected. An oral glucose tolerance test (OGTT) was performed 60min after oral administration of each plant extract solution at 500mg.kg^<-1> BW. Compared to the control, peak blood glucose concentrations during the OGTT (30min) were significantly lower in rats administered with 13 plant extracts, especially for Asparagus officinalis L, Chamaerion angustifolium, Dasiphora fruticosa, Euphorbia humifusa Willd, Filix maris, Ferula feruloides, Fomes fomentaricus, Brain, Malva mohileviensi, Momoridicae cochinchinensidi, Schizonepeta multida, Sophora alopecuroides, and Vaccinium vitis idea (p<0.05). These results suggest that specific Mongolian medicinal plants may have a glucose absorption inhibiting effect. In conclusion, this study provides novel evidence that Mongolian medicinal plant extracts can control blood glucose rising in rats. We hope that the outcomes of the present study will motivate further investigation on the usefulness of Mongolian medicinal plants concerning the treatment of type 2 diabetes.
和漢医薬学会の論文