肉腫ノ皮膚轉移ニ關スル實驗的研究
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Numerous examinations of the transplantation of sarcoma were made, but only a few cases of cutaneous metastasis were noticed. The author was anxious to know whether he could find metastasis in the skin, as in the other organs, within a certain space of time after a transplantation. He transplanted a piece of transmissible sarcoma-spindle-celled sarcoma-of rabbit, which was detected by Kato in 1918, into a subfascial space of an auricular basis. He, of course, regarded it as a primary focus of sarcoma and watched for the appearance of metastasis in the internal organs as well as in the skin. The results obtained were as follows: -1) There was no case of metastasis in the skin when it received some stimulation such as scarification, crushing, application of tar, radiation of ultra-violet rays before the transplantation. 2) There occurred two cases of skin metastasis among ten. One was a case where the ovaries had been exstirpated before the transplantation took place. This case died sixty one days after the exstirpation, or forty one days after the transplantation. There were found seven metastases in the right breast, -one bean sized, two pea sized and four millet sized. The other was a case where the ovaries were exstirpated after the transplantation. This died seventy five days after the exstirpation, or one hundred and two days after the transplantation. There were found two metastases in the lumbar part; one bean sized, on the right side, the other, pea sized, on the left side. 3) No cutaneous metastasis occurred when the testicles were exstirpatsd before the transplantation. 4) There were four cases of metastasis in the skin on injecting human urine, 5c.c. five times before, and 15c.c. five times after, the transplantation. The first died thirty four days after the transplantation and showed two metastases; one in the right breast, pea sized, the other in the left breast, about the size of the tip of the little finger. The second died fifty one days after the transplantation and there were found two metastases; one in the right breast, 1.5×1.0c.m. in size the other in the right abdomen, as large as the tip of the little finger. The third died forty five days after the transplantation, and there appeared five metastases in the right abdomen. Their size ranged from a grain of rice to a pea. The fourth died sixty four days after the transplantation, and showed metastasis in both sides of the abdomen, both being the size of a bean. 5) There was no cutaneous metastasis in those cases which received intravenous injection of one per cent indian ink (10c.c. twenty times) before the transplanta-tion. The succesful cases of metastasis were only six out of eighty one. It may be said, therefore, that the skin seemed to be a unfavourable organ for metastasis owing to its diathetic circumstances. It was hard to explain how the exstirpation of the ovaries and the injection of human urine were concerned in the formation of metastasis in any way, but it seems that it acted.
- 京都府立医科大学の論文
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