Determination of Sweroside in Rat Plasma and Bile for Oral Bioavailability and Hepatobiliary Excretion
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概要
- 論文の詳細を見る
Sweroside is an active ingredient of iridoid glycoside isolated from the flower buds of Lonicera japonica THUNB. A quantitative HPLC-UV method was developed for monitoring sweroside in rat plasma, urine, feces and bile. The method was successfully applied for a basic pharmacokinetic study. The obtained data of pharmacokinetics were applied to evaluate the oral bioavailabilities of sweroside and the active ingredients of purified herbal extracts (IGEs-1). The absolute bioavailability was estimated to F_<sweroside> 0.31% and F_<IGEs-1> 0.67%. The majority of sweroside excreted to feces revealed one reason of the low oral bioavailability. The values of F_<IGEs-1> much higher than that of F_<sweroside> reveals that ingredients in IGEs-1 such as loganin, secoxyloganin and some phenolic acids may promote the absorption of sweroside. The study of hepatobiliary excretion was achieved by an in vivo microdialysis sampling method after intravenous administration of sweroside. The percentage of accumulation of free form sweroside in bile duct was 31.2±7.2% of the total dosage. It may be one reason why sweroside possesses strong hepatoprotective effect.
- 社団法人日本薬学会の論文
- 2009-01-01
著者
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Cao Jun
Key Laboratory Of Animal Models And Human Disease Mechanisms And Laboratory Of Learning And Memory K
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Chen Jun
Department of Urology, National Taiwan University Hospital
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WEN Xiao-Dong
Key Laboratory of Modern Chinese Medicines (China Pharmaceutical University), Ministry of Education
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LI Ping
Key Laboratory of Modern Chinese Medicines (China Pharmaceutical University), Ministry of Education
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Cao Jun
Department Of Pharmacognosy China Pharmaceutical University
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LUO Yong-Dong
Key Laboratory of Modern Chinese Medicines, Ministry of Education, China Pharmaceutical University
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WEN Xiao-Dong
Department of Pharmacognosy, China Pharmaceutical University
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Li Ping
Key Laboratory Of Modern Chinese Medicines Ministry Of Education China Pharmaceutical University:dep
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Li Ping
Key Laboratory Of Modern Chinese Medicines (china Pharmaceutical University) Ministry Of Education:d
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Wen Xiao-dong
Dep. Of Pharmacognosy China Pharmaceutical Univ.
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Wen Xiao-dong
Department Of Pharmacognosy China Pharmaceutical University
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Luo Yong-dong
Key Laboratory Of Modern Chinese Medicines Ministry Of Education China Pharmaceutical University
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Chen Jun
Department Of Earth Sciences Nanjing University
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Li Ping
Key Lab. Of Heavy Ion Radiation Biology And Medicine Of Chinese Acad. Of Sciences
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Chen Jun
Department Of Biomedical Engineering Division Of Orthopaedic Surgery Department Of Surgery Duke University
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