Sesquiterpenes from Ainsliaea fragrans and Their Inhibitory Activities against Cyclooxygenases-1 and 2
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概要
- 論文の詳細を見る
One new guaiane-type sesquiterpene glycoside, 2′-O-E-caffeoyl-8α-hydroxy-11α,13-dihydro-3β-O-β-D-glucozaluzanin C (1), was isolated from the whole herb of Ainsliaea fragrans (Compositae), together with five known sesquiterpene lactones: 8α-hydroxy-11α,13-dihydro-3β-O-β-D-glucozaluzanin C (2), 8α-hydroxy-11α,13-dihydrozaluzanin C (3), 3α-hydroxy-11β,13-dihydro-8α-O-β-D-glucozaluzanin C (4), 3β-hydroxy-11β,13-dihydro-8α-O-β-D-glucozaluzanin C (5), 3β-O-β-D-glucozaluzanin C (6). The structures of isolated compounds were established by means of 1D and 2D NMR spectroscopy and chemical methods. All isolates obtained in the present study were evaluated for their inhibitory effects against cyclooxygenases-1 and 2 in vitro, and the structure–activity relationships were also discussed.
- 公益社団法人 日本薬学会の論文
著者
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Zhang Lu-yong
National Drug Screening Lab. China Pharmceutical Univ.
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LI Ping
Key Laboratory of Modern Chinese Medicines (China Pharmaceutical University), Ministry of Education
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Wang H
Peking Univ. Beijing Chn
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Wang Hao
中華人民共和国
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Wang Hao
State Key Lab Of Advanced Technology For Materials Synthesis And Processing Wuhan University Of Tech
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Ye Wen-Cai
Department of Phytochemistry, China Pharmaceutical University
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Yan Ming
National Center Of New Drug Screening China Pharmaceutical University
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Wang Hao
Dep. Of Natural Medicinal Chemistry China Pharmaceutical Univ.
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Ye Wen-cai
Department Of Natural Medicinal Chemistry China Pharmaceutical University:institute Of Traditional C
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Wu Ting
Department Of Neurology The First Affiliated Hospital Of Nanjing Medical University
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Wang H
Department Of Natural Medicinal Chemistry China Pharmaceutical University
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Wang Hao
Key Laboratory of Modern Chinese Medicine, China Pharmceutical University
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Liu Ge
Department of Natural Medicinal Chemistry, China Pharmceutical University
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Zhang Xiao-Qi
Guangdong Province Key Laboratory of Pharmcodynamic Constituents of TCM and New Drugs Research, Jina
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Liu Ge
Department Of Biochemistry Case Western Reserve University School Of Medicine
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Li Ping
Key Lab. Of Heavy Ion Radiation Biology And Medicine Of Chinese Acad. Of Sciences
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Wu Ting
Department Of Chemistry East China Normal University
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Ye Wen-Cai
Department of Natural Medicinal Chemistry, China Pharmceutical University
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Wu Ting
Department of Natural Medicinal Chemistry, China Pharmceutical University
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Li Ping
Key Laboratory of Modern Chinese Medicine, China Pharmceutical University
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Zhang Xiao-Qi
Guangdong Province Key Laboratory of Pharmcodynamic Constituents of TCM and New Drugs Research, Jinan University
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