Pharmacodynamic Parameters of Immunosuppressive Drugs Are Not Correlated with Age, Duration of Dialysis, Percentage of Lymphocytes or Lymphocyte Stimulation Index in Renal Transplant Recipients(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
The lymphocyte immunosuppressant-sensitivity test (LIST) has been reported extensively as being able to estimate the pharmacological efficacy of immunosuppressive drugs in individual patients. This study measured the IC_<50> values for 6 drugs, cyclosporine, tacrolimus, methylprednisolone, 6-mercaptopurine, mycophenolic acid, and mizoribine, against mitogen-induced proliferation of peripheral-blood lymphocytes in 29 renal transplant recipients. We also examined relationship between the IC_<50> values and 4 factors; age, duraton of dialysis, percentage of lymphocytes in total white blood cells, and blastogenesis stimulation index by mitogen. There were no significant correlations between the IC_<50> values and these factors, except that the tacrolimus IC_<50> value was no significant correlations between the IC_<50> values and these factors, except that the tacrolimus IC_<50> value was correlated weakly with the stimulation index (p<0.05, r=-0.429). It was concluded that the pharmacological efficacy of immunosuppressive drugs cannot be inferred from the patient characteristics or their laboratory data. LIST is an effective method to elucidate the pharmacodynamic properties of immunosuppressive agents in individual renal transplant recipients without being influenced by the recipient clinical data.
- 公益社団法人日本薬学会の論文
- 2008-11-01
著者
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HIRANO Toshihiko
Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Sciences
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SAITO Noriko
Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Ni
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Satoh Hiroshi
Division Of Cardiology Internal Medicine Iii Hamamatsu University School Of Medicine
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Kasahara Takashi
Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
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TAKAHASHI Kota
Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical
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NAKAGAWA Yuki
Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical
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SAITO Kazuhide
Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical
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TAKAHASHI Kota
Niigata University of School of Medicine
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Saito Noriko
Division Of Clinical Nephrology And Rheumatology Graduate School Of Medical And Dental Sciences Niig
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Nakagawa Yuki
Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
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Takahashi Kota
新潟大学 医歯学総合研究科腎・泌尿器病態学分野
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Takahashi Kota
Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
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Saito Kazuhide
Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
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Hirano Toshihiko
Department Of Clinical Pharmacology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Isogai Kazuya
Division of Pharmacy, Niigata University Medical & Dental Hospital
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Toyama Akira
Division of Pharmacy, Niigata University Medical & Dental Hospital
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Takahashi Kota
Division Of Urology Department Of Regenerative And Transplant Medicine Niigata University Graduate S
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Saito Kazuhide
Department Of Urology Niigata University School Of Medicine
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Toyama Akira
Division Of Pharmacy Niigata University Medical & Dental Hospital
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Toyama Akira
Division Of Pharmacy Niigata University Medical And Dental Hospital
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Isogai Kazuya
Division Of Pharmacy Niigata University Medical & Dental Hospital
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Isogai Kazuya
Division Of Pharmacy Niigata University Medical And Dental Hospital
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SUGIYAMA Kentaro
Division of Pharmacy, Niigata University Medical and Dental Hospital
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TASAKI Masayuki
Division of Urology, Graduate School of Medical and Dental Sciences, Niigata University
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Tasaki Masayuki
Division Of Urology Graduate School Of Medical And Dental Sciences Niigata University
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Takahashi Kota
Niigata University School Of Medicine
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Satoh Hiroshi
Division Of Pharmacy Niigata University Medical And Dental Hospital
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Takahashi Kota
Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
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Takahashi Kota
Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
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Takahashi Kota
Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
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Saito Noriko
Division Of Clinical Nephrology Rheumatology Respiratory Medicine And Infection Control And Preventi
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Sugiyama Kentaro
Division Of Pharmacy Niigata University Medical And Dental Hospital
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Tasaki Masayuki
Division Of Urology Department Of Regenerative And Transplant Medicine Niigata University Graduate S
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