Pharmacodynamic Parameters of Immunosuppressive Drugs Are Not Correlated with Age, Duration of Dialysis, Percentage of Lymphocytes or Lymphocyte Stimulation Index in Renal Transplant Recipients(Pharmacology)

元データ 2008-11-01 公益社団法人日本薬学会

概要

The lymphocyte immunosuppressant-sensitivity test (LIST) has been reported extensively as being able to estimate the pharmacological efficacy of immunosuppressive drugs in individual patients. This study measured the IC_<50> values for 6 drugs, cyclosporine, tacrolimus, methylprednisolone, 6-mercaptopurine, mycophenolic acid, and mizoribine, against mitogen-induced proliferation of peripheral-blood lymphocytes in 29 renal transplant recipients. We also examined relationship between the IC_<50> values and 4 factors; age, duraton of dialysis, percentage of lymphocytes in total white blood cells, and blastogenesis stimulation index by mitogen. There were no significant correlations between the IC_<50> values and these factors, except that the tacrolimus IC_<50> value was no significant correlations between the IC_<50> values and these factors, except that the tacrolimus IC_<50> value was correlated weakly with the stimulation index (p<0.05, r=-0.429). It was concluded that the pharmacological efficacy of immunosuppressive drugs cannot be inferred from the patient characteristics or their laboratory data. LIST is an effective method to elucidate the pharmacodynamic properties of immunosuppressive agents in individual renal transplant recipients without being influenced by the recipient clinical data.

著者

HIRANO Toshihiko Department of Clinical Pharmacology, Tokyo University of Pharmacy and Life Sciences
SAITO Noriko Division of Clinical Nephrology and Rheumatology, Graduate School of Medical and Dental Sciences, Ni
Satoh Hiroshi Division Of Cardiology Internal Medicine Iii Hamamatsu University School Of Medicine
Kasahara Takashi Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
TAKAHASHI Kota Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical
NAKAGAWA Yuki Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical
SAITO Kazuhide Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical
TAKAHASHI Kota Niigata University of School of Medicine
Saito Noriko Division Of Clinical Nephrology And Rheumatology Graduate School Of Medical And Dental Sciences Niig
Nakagawa Yuki Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
Takahashi Kota 新潟大学 医歯学総合研究科腎・泌尿器病態学分野
Takahashi Kota Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
Saito Kazuhide Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
Hirano Toshihiko Department Of Clinical Pharmacology School Of Pharmacy Tokyo University Of Pharmacy And Life Science
Isogai Kazuya Division of Pharmacy, Niigata University Medical & Dental Hospital
Toyama Akira Division of Pharmacy, Niigata University Medical & Dental Hospital
Takahashi Kota Division Of Urology Department Of Regenerative And Transplant Medicine Niigata University Graduate S
Saito Kazuhide Department Of Urology Niigata University School Of Medicine
Toyama Akira Division Of Pharmacy Niigata University Medical & Dental Hospital
Toyama Akira Division Of Pharmacy Niigata University Medical And Dental Hospital
Isogai Kazuya Division Of Pharmacy Niigata University Medical & Dental Hospital
Isogai Kazuya Division Of Pharmacy Niigata University Medical And Dental Hospital
SUGIYAMA Kentaro Division of Pharmacy, Niigata University Medical and Dental Hospital
TASAKI Masayuki Division of Urology, Graduate School of Medical and Dental Sciences, Niigata University
Tasaki Masayuki Division Of Urology Graduate School Of Medical And Dental Sciences Niigata University
Takahashi Kota Niigata University School Of Medicine
Satoh Hiroshi Division Of Pharmacy Niigata University Medical And Dental Hospital
Takahashi Kota Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
Takahashi Kota Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
Takahashi Kota Division Of Urology Department Of Regenerative And Transplant Medicine Graduate School Of Medical An
Saito Noriko Division Of Clinical Nephrology Rheumatology Respiratory Medicine And Infection Control And Preventi
Sugiyama Kentaro Division Of Pharmacy Niigata University Medical And Dental Hospital
Tasaki Masayuki Division Of Urology Department Of Regenerative And Transplant Medicine Niigata University Graduate S

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