Pulmonary Arterial Hypertension Caused by Treatment with Dasatinib for Chronic Myeloid Leukemia -Critical Alert-
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概要
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We present a case of pulmonary arterial hypertension (PAH), which is potentially related to treatment with dasatinib (Sprycel®). A 61-year-old woman, who had been treated with dasatinib for 27 months for chronic myeloid leukemia (CML), visited our hospital complaining of dyspnea. In right heart catheterization, her mean pulmonary arterial pressure was 35 mmHg. After other possible etiologies to cause PAH were excluded, the patient was diagnosed as a dasatinib-related PAH. As notified by U.S. Food and Drug Administration (FDA) in October 2011, we recommend routine cardiopulmonary evaluation before and during treatment with dasatinib in CML patients in terms of the adverse effects of PAH.
著者
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Satoh Hiroshi
Division Of Cardiology Internal Medicine Iii Hamamatsu University School Of Medicine
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Katoh Hideki
Division Of Cardiology Internal Medicine Iii Hamamatsu University School Of Medicine
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Hayashi Hideharu
Division Of Cardiology Internal Medicine Iii Hamamatsu University School Of Medicine
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Urushida Tsuyoshi
Division Of Cardiology Internal Medicine Iii Hamamatsu University School Of Medicine
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Saotome Masao
Division Of Cardiology Internal Medicine Iii Hamamatsu University School Of Medicine
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OHNISHI Kazunori
Division of Hematology, Department of Medicine III, Hamamatsu University School of Medicine
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Urushida Tsuyoshi
Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Japan
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Saotome Masao
Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Japan
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Sano Makoto
Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Japan
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Hayashi Hideharu
Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Japan
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