5 臨床から分離したバイオフィルム形成性Streptococcus intermediusの分子生物学的解析(第514回大阪歯科学会例会)

概要

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Most bacteria in natural environments form communities, which are commonly referred to as biofilms. Previously, we reported that biofilm formation by oral bacteria have an impact on pathogenesis and plays a key role in development of persistent infections. Using a 96-well microtiter crystal violet (CV) plate assay, we determined the capacity of biofilm-formation of Streptococcus intermedius clinical isolates. The CV analysis showed that glucose increased biofilm-formation of the organism. Furthermore, we isolated the homolog to the pgcA gene, which codes α-phosphoglucomutase in Bacillus subtilis. However, we found that pgcA gene inactivation did not stop biofilm-formation of Streptococcus intermedius.
大阪歯科学会の論文
2008-06-25