P-46 植物培養細胞によるフラボンとイソフラボンの配糖化反応(ポスター発表の部)

概要

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Flavonoids are phenolic compounds widely present in plants and foods of plant origin. Taxifolin, chrysin, querucetin and kaempferol are type of flavons, and then daidzein and genistein are type of isoflavons. Taxiforin is included in Larix sibirica. Chrysin and querucetin are included in peel of citrous. Kaempferol is included in tea leaves. Daidzein and genistein exist in soy beens. These compounds are known to have the biological activities including an antioxidant property, anti-inflammatory and carcinogenic depression effects. These compounds are used as agents and food ingredients. Irrespective of such biological activities, the use of these compounds has been limited, because of their low solubility. Higher plants accumulate a wide range of glycosides as secondary metabolites, and are capable of conjugating sugar residues not only to endogenous metabolic intermediates but also to xenobiotics. To enhance the water-solubility of their flavonoids,we investigated the glycosylation using Eucalyptus perriniana. Eucalyptus perriniana plant cultured cells were tested for the glycosylation toward there compounds. As a result, Chrysin, daidzein and genistein were glycosylated at C7-position of hydroxyl group in the substrate molecules. Querucetin and kaempferol were glycosylated at C3-position of hydroxyl group. Taxifolin was glycosylated at C7, C5'-position of hydroxyl group.
天然有機化合物討論会の論文
2007-08-24