105(P58) ヒガンフグ骨格筋Na^+チャンネルとテトロドトキシン耐性について(ポスター発表の部)

概要

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A full-length cDNA, encoding of an entire four domains voltage gated Na+ channel α subunit (fMNa1, 1880 amino acid) from skeletal muscle of highly toxic puffer fish, Fugu pardalis, with its putative alternative splicing variants which predict one or two domains proteins. The residues for ion selective filter and voltage-sensor, and the charged residues in SS1 and SS2 regions of Repeat I-IV in fMNa1 are all conserved as the other Na+ channels reported previously. Interestingly, the aromatic amino acid (Phe/Try) commonly locating in SS2 region of Repeat I of tetrodotoxin-sensitive Na+ channels, is replaced by Asn in pfMNa1. Similar amino acid substitutions with the nonaromatic residue at this position were observed in the other tetrodotoxin-resistant Na+ channel proteins, and were proved to be critical for their resistivity.
天然有機化合物討論会の論文
1999-09-01